Differential effects of white matter hyperintensity on geriatric depressive symptoms according to APOE-ε4 status
| Autor: | Duk L. Na, Dae Ryong Kang, Joung Hwan Back, Ki Young Lim, Seong Hye Choi, Sang Won Seo, Hyun Woong Roh, Jayoun Kim, Sang Joon Son, Kang Soo Lee, Ki Jung Chang, Si Heon Kim, Yunhwan Lee, Byung Hoon Oh, Seong Yoon Kim, Chang Hyung Hong, Jai Sung Noh, Do-Kwan Kim, Young Ki Chung |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Gerontology Apolipoprotein E medicine.medical_specialty Genotype Endophenotypes Apolipoprotein E4 Neuroimaging behavioral disciplines and activities Late Onset Disorders White matter Risk Factors Internal medicine mental disorders Humans Medicine Risk factor Geriatric Assessment Depression (differential diagnoses) Aged Aged 80 and over Mini–Mental State Examination medicine.diagnostic_test Depression business.industry Middle Aged Magnetic Resonance Imaging White Matter Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Endophenotype Disease Progression Linear Models Female Geriatric Depression Scale business |
| Zdroj: | Journal of Affective Disorders. 188:28-34 |
| ISSN: | 0165-0327 |
| Popis: | Background We aimed to examine differential effects of WMH on progression of depressive symptoms according to APOE e4 status in the elderly. Methods We obtained data from elderly Korean subjects ( n =707) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A linear mixed model stratified according to APOE genotype (APOE e4 carrier vs. non-carrier) was constructed using GDS score as a primary outcome and degree of overall, deep, periventricular WMH evaluated by a visual rating scale as a risk factor of interest. We also tested interaction between APOE e4, WMH and time as predictors of clinical progression on GDS scores to examine the moderating effect of APOE e4 allele on the relationship between degree of WMH and progression of geriatric depressive symptoms. Results The mean (SD) follow-up duration of the participants was 2.0 (0.8) years. Among APOE e4 carriers, a severe degree of overall and deep WMH, but not periventricular WMH, predicted progression of geriatric depressive symptoms (overall WMH: coefficient=0.96, p =0.010; deep WMH: 0.87, p =0.016). There were significant interaction between APOE e4, degree of WMH and time in predicting GDS increase (5d f , F =2.28, p =0.046). Limitations Only subjects seeking medical attention and with follow-up measurements were enrolled in this study. Specific location of WMH and use of antidepressant were uncontrolled. Conclusions Considering biological markers such as degree of WMH and APOE e4 status may be clinically relevant to predicting progression of geriatric depressive symptoms. |
| Databáze: | OpenAIRE |
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