Response to drugs in schizophrenia: the influence of family history, obstetric complications and ventricular enlargement
| Autor: | Robin M. Murray, L E Tune, Vishwajit L. Nimgaonkar, Simon Wessely |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Psychosis Pediatrics medicine.medical_specialty Chlorpromazine medicine.medical_treatment Neurocognitive Disorders Cerebral Ventricles Risk Factors medicine Familial predisposition Humans Family history Prospective cohort study Antipsychotic Applied Psychology business.industry medicine.disease Prognosis Surgery Psychiatry and Mental health Schizophrenia Brain Damage Chronic Female Schizophrenic Psychology Age of onset business Tomography X-Ray Computed medicine.drug Antipsychotic Agents |
| Zdroj: | Psychological medicine. 18(3) |
| ISSN: | 0033-2917 |
| Popis: | SynopsisA prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|