19-Aldehydo-4-Androstene-3,17-Dione: An Estrogen Precursor that Inhibits Sebaceous Secretion in a Rat Model

Autor:	F J, Ebling, V, Petrow
Rok vydání:	1993
Předmět:	Uterus Androstenedione Estrogens Organ Size Cell Biology Dermatology Models Biological Biochemistry Clitoris Rats Sebum Sebaceous Glands Animals Female Prodrugs Molecular Biology
Zdroj:	Journal of Investigative Dermatology. 101:121S-123S
ISSN:	1523-1747 0022-202X
Popis:	19-aldehydo-4-androstene-3,17-dione (A; R = CHO), a biogenetic precursor of estrone in the body, has been found to suppress sebum secretion in the ovariectomized testosterone-treated Wistar rat at 1/2000 times the dose of cyproterone acetate required to produce an equivalent effect. The action of this steroid must therefore be analogous to that of an estrogen even though, in striking contrast to estradiol, it is without effect on uterine weight or vaginal cornification. It is postulated that 19-aldehydo-4-androstene-3,17-dione (A; R = CHO) is converted locally into estrone (B) by aromatase present in skin but only in low concentrations in vagina and uterus. The potential of biogenetic precursors (I) of estrogens for therapy of acne or alleviation of the worst effects of skin aging is worth investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a29cdeff7a33aaa519f5755ff63f760 https://doi.org/10.1111/1523-1747.ep12363120 Zobrazit plný text záznamu