A lineage-related reciprocal inhibition circuitry for sensory-motor action selection
| Autor: | Gerald Vinatier, Vincenzo G. Fiore, Edgar Buhl, Danielle C. Diaper, Benjamin L. de Bivort, Chenghao Chen, Raymond J. Dolan, Frank Hirth, Zoe N. Ludlow, Keita Endo, Yoshitsugu Adachi, Sheena Brown, James J L Hodge, Kei Ito, Nicholas J. Strausfeld, Stephan J. Sigrist, Daniel A. Solomon, Jean-René Martin, Alan Stepto, Katherine E. White, Dickon M. Humphrey, Sean M. Buchanan, Richard Faville, Ralf Stanewsky, Benjamin Kottler, Jonah Dearlove |
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| Přispěvatelé: | Department of Psychology, King's College, Institute of Psychiatry, University of London, Wellcome Trust Centre for Neuroimaging, University College of London [London] (UCL), University of Bristol [Bristol], Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Department of Neuroscience, University of Arizona, Department of Cell and Developmental Biology, University College London, Department of Organismic & Evolutionary Biology, Center for Brain Science, Department of Genetics, Institute for Biology, Free University Berlin, Free University of Berlin (FU), Laboratory of Molecular Genetics Department of Molecular Biology Institute of Molecular and Cellular Biosciences Japon (LMG), The University of Tokyo (UTokyo) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Stem Cell Lineage
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Sensory system Gating Neural Circuit Biology Inhibitory postsynaptic potential 03 medical and health sciences GABA 0302 clinical medicine Neuroblast medicine Behaviour 030304 developmental biology 0303 health sciences [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Central Complex Reciprocal inhibition [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Action Selection medicine.anatomical_structure Drosophila melanogaster Disinhibition Leaky Integrator Model Forebrain Neuron medicine.symptom Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | BioRxiv |
| Popis: | The insect central complex and vertebrate basal ganglia are forebrain centres involved in selection and maintenance of behavioural actions. However, little is known about the formation of the underlying circuits, or how they integrate sensory information for motor actions. Here, we show that paired embryonic neuroblasts generate central complex ring neurons that mediate sensory-motor transformation and action selection in Drosophila. Lineage analysis resolves four ring neuron subtypes, R1-R4, that form GABAergic inhibition circuitry among inhibitory sister cells. Genetic manipulations, together with functional imaging, demonstrate subtype-specific R neurons mediate the selection and maintenance of behavioural activity. A computational model substantiates genetic and behavioural observations suggesting that R neuron circuitry functions as salience detector using competitive inhibition to amplify, maintain or switch between activity states. The resultant gating mechanism translates facilitation, inhibition and disinhibition of behavioural activity as R neuron functions into selection of motor actions and their organisation into action sequences. |
| Databáze: | OpenAIRE |
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