Effect of Photosensitizer Delivery System and Irradiation Parameters on the Efficiency of Photodynamic Therapy of B16 Pigmented Melanoma in Mice
| Autor: | Marina Soncin, Michael A. J. Rodgers, Boris D. Rihter, Roberta Biolo, Malcolm E. Kenney, Giulio Jori |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_treatment
Melanoma Experimental Photodynamic therapy Biochemistry Melanin Mice chemistry.chemical_compound Optics medicine Animals Photosensitizer Irradiation Physical and Theoretical Chemistry Drug Carriers Liposome Photosensitizing Agents Naphthalocyanine business.industry Chemistry Melanoma General Medicine medicine.disease Mice Inbred C57BL Photochemotherapy Liposomes Cancer research Female business Drug carrier Neoplasm Transplantation |
| Zdroj: | Photochemistry and Photobiology. 63:224-228 |
| ISSN: | 1751-1097 0031-8655 |
| DOI: | 10.1111/j.1751-1097.1996.tb03018.x |
| Popis: | Previous studies (Biolo et al., Photochem. Photobiol. 59, 362-365, 1994) showed that liposome-delivered Si(IV)-naphthalocyanine (SiNc) photosensitizes B16 pigmented melanoma subcutaneously transplanted in C57 mice to the action of 776 nm light. However, the efficacy of the phototreatment was limited by a lack of selectivity of tumor targeting by SiNc as well as by incomplete necrosis of the neoplastic mass. The present investigations show that the use of a different delivery system (Cremophor emulsion vs liposomes of dipalmitoylphosphatidylcholine) causes no significant increase in the selectivity of tumor targeting for three injected doses of SiNc (0.5, 1, 2 mg/kg). However, upon 776 nm light irradiation (300 mW/cm2; 520 J/cm2), the delay in the rate of tumor growth was maximal (7-8 days) for the highest naphthalocyanine dose. On the other hand, a remarkable improvement in the tumor response was obtained by inducing an intratumoral temperature increase to 44 degrees C immediately after PDT. The thermal effect appeared to be due to photoexcitation of melanin by 776 nm light (550 mW/cm2; 520 J/cm2) and subsequent partial conversion of absorbed energy into heat. |
| Databáze: | OpenAIRE |
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