Intra-Arterial Prostaglandin E1Infusion in Patients with Rest Pain: Short-Term Results
| Autor: | D. Mourikis, K. Katsenis, Achilleas Chatziioannou, V. Koutoulidis, A. Dalakidis |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Article Subject lcsh:Medicine Pain lcsh:Technology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Port (medical) Infusion therapy medicine.artery medicine Humans Infusions Intra-Arterial Alprostadil lcsh:Science Prostaglandin E1 Rest (music) Aged General Environmental Science lcsh:T Vascular disease business.industry lcsh:R External iliac artery General Medicine Middle Aged medicine.disease Surgery Peripheral Catheter chemistry Anesthesia lcsh:Q business Research Article |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2012 (2012) |
| ISSN: | 1537-744X |
| Popis: | Purpose. To present our results after short-term (1 month) intra-arterial infusion therapy of PGE1-alprostadil via a port system implanted in the ipsilateral external iliac artery (EIA) in patients with severe rest pain.Methods. Ten patients with severe rest pain were included. All patients showed extensive peripheral vascular disease below the knee. The tip of the catheter was introduced via a retrograde puncture in the ipsilateral external iliac artery (EIA). The patients received intraarterial infusion of PGE1, 20 mgr alprostadil daily, via the port catheter for 1 month.Results. Clinical success was evaluated according to subjective grading of pain (group A significant decrease, group B moderate decrease and group C no response). A significant decrease of rest pain was observed in 8 (group A, 80%) patients, a moderate decrease in 2 (Group B, 20%), whereas no patients demonstrated any significant response. Both patients of group B had Buergers' disease and continue to smoke during therapy. No peripheral thrombosis or clinical deterioration was noticed.Conclusion. Intraarterial infusion of PGE1alprostadil on a daily basis, using a port catheter into the ipsilateral EIA, in selected patients with severe rest pain, seems to be very effective, without any serious complications. |
| Databáze: | OpenAIRE |
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