Digestive absorption of silicon, supplemented as orthosilicic acid-vanillin complex
| Autor: | Guiseppe Rinaldi, Béatrice Housez, Aline Marcowycz, Murielle Cazaubiel, Karine Croizet, Corinne Maudet |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Silicon Silicic Acid Urine Absorption (skin) Excretion Beverages chemistry.chemical_compound Young Adult Double-Blind Method Ingestion Humans Silicic acid Chromatography Cross-Over Studies Vanillin Area under the curve Bioavailability Kinetics Renal Elimination chemistry Intestinal Absorption Solubility Benzaldehydes Dietary Supplements Food Fortified Digestion Female Food Additives Nutritive Value Food Science Biotechnology |
| Zdroj: | Molecular nutritionfood research. 59(8) |
| ISSN: | 1613-4133 |
| Popis: | Scope Silicon (Si) is an abundant element on earth. It is found naturally in water in the form of orthosilicic acid (OSA), however this form is not stable under certain conditions such as in highly concentrated and non-neutral pH solutions, which lead to its polymerization and reduced bioavailability. This study aimed to assess the bioavailability of Si from OSA stabilized by vanillin (OSA-VC). Methods and results This was a single-center, double-blind, cross-over randomized controlled trial. Fourteen healthy subjects were recruited and consumed either OSA-VC or a placebo on two separate occasions. Blood and urine samples were collected during 6 h following ingestion and analyzed to determine Si absorption and excretion. Plasma Si area under the curve (0–6 h) was significantly higher after OSA-VC ingestion compared to placebo ingestion (p = 0.0002). Significantly higher urinary Si excretion was also reported over the 6-h period after OSA-VC ingestion compared to placebo (p |
| Databáze: | OpenAIRE |
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