The utility of routine pre-chemotherapy screening with cardiac gated blood pool scan for patients at low risk of anthracycline toxicity
| Autor: | K Chiang, Raymond Snyder, Puey Ling Chia, Anthony Dowling |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Anthracycline Heart Diseases medicine.medical_treatment 030204 cardiovascular system & hematology 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Internal medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Pharmacology (medical) Doxorubicin Anthracyclines Aged Retrospective Studies Aged 80 and over Cardiotoxicity Chemotherapy Ejection fraction Antibiotics Antineoplastic business.industry Cancer Retrospective cohort study Stroke Volume Stroke volume Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Female Radiology business medicine.drug |
| Zdroj: | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 24(4) |
| ISSN: | 1477-092X |
| Popis: | Background Anthracycline-based chemotherapy is used in many malignancies. Current recommendations by several groups suggest cardiac monitoring prior to and during anthracycline therapy. We aim to review the usefulness of baseline cardiac screening for left ventricular ejection fraction to assess if it had any impact on chemotherapy decisions in patients to be treated with anthracycline-based regimens or any beneficial effect upon outcomes. Methods We conducted a retrospective three-year audit of cancer patients who underwent GBPS prior to anthracycline (doxorubicin) chemotherapy. Subjects were identified via records from the Department of Nuclear Medicine. Pharmacy dispensing records identified those who received doxorubicin. Patient demographics, cancer type, cardiac risk factors, GBPS ejection fraction (EF), and cumulative anthracycline dose were collected. Results From 1 August 2009 to 31 July 2012, 179 patients underwent GBPS pre-doxorubicin chemotherapy. The mean age was 59 years (range 21–89 years), with 51% being males. Only two patients (1.1%) had an abnormal EF Conclusion Only 1.1% of the screened patients had EF |
| Databáze: | OpenAIRE |
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