Detection of the tumor-associated glycoprotein antigen (TAG-72) in premalignant lesions of the colon
| Autor: | Ronald R. Salem, Leonard S. Gottlieb, Glenn Steele, Deborah DeCoste, D'Emilia Jc, Henry F. Sears, Barbara C. Wolf |
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| Rok vydání: | 1989 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Adenoma Colonic Polyps Malignant transformation Antigen Crohn Disease Antigens Neoplasm medicine Humans Glycoproteins biology Immunoperoxidase business.industry Antibodies Monoclonal medicine.disease Immunohistochemistry digestive system diseases Oncology Dysplasia biology.protein Colitis Ulcerative Tumor-associated glycoprotein 72 Antibody business Colorectal Neoplasms Precancerous Conditions |
| Zdroj: | Journal of the National Cancer Institute. 81(24) |
| ISSN: | 0027-8874 |
| Popis: | We used monoclonal antibody B72.3 to study the expression of the colorectal carcinoma-associated antigen TAG-72 in premalignant colonic lesions with the immunoperoxidase technique. This antigen, which is rarely detectable in the normal colonic epithelium, was expressed in 13 of 19 adenomas with moderate to severe dysplasia and nine of nine cases of inflammatory bowel disease. The antibody reacted with the normal-appearing mucosa adjacent to a carcinoma in 10 of 12 cases, although only eight of the tumors expressed the antigen. The expression of the TAG-72 antigen in the colonic epithelium may be an early marker of malignant transformation. |
| Databáze: | OpenAIRE |
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