Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs
| Autor: | Mazzola S., Albertini M., Ciminaghi B., Lavitrano M., Otterbein L. E., Bach F. H., Clement M. G., FORNI, MONICA, BACCI, MARIA LAURA, ZANNONI, AUGUSTA, GENTILINI, FABIO |
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| Přispěvatelé: | Mazzola S., Forni M., Albertini M., Bacci M.L., Zannoni A., Gentilini F., Ciminaghi B., Lavitrano M., Otterbein L.E., Bach F.H., Clement M.G., Mazzola, S, Forni, M, Albertini, M, Bacci, M, Zannoni, A, Gentilini, F, Lavitrano, M, Bach, F, Otterbein, L, Clement, M |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Lipopolysaccharides
LPS End organ damage Swine Anti-Inflammatory Agents Apoptosis Heme Pharmacology Lung injury Biochemistry Models Biological Intensive care Genetics medicine Animals HEME OXYGENASE Molecular Biology Blood Coagulation Lung Disseminated intravascular coagulation business.industry CARBON MONOXIDE medicine.disease Intercellular Adhesion Molecule-1 Respiration Disorders Pulmonary hypertension Shock Septic Interleukin-10 Up-Regulation CO Oxygen Disease Models Animal medicine.anatomical_structure Carboxyhemoglobin Shock (circulatory) Anesthesia Heme Oxygenase (Decyclizing) Liver function medicine.symptom business Heme Oxygenase-1 Biotechnology |
| Popis: | Endotoxic shock, one of the most prominent causes of mortality in intensive care units, is characterized by pulmonary hypertension, systemic hypotension, heart failure, widespread endothelial activation/ injury, and clotting culminating in disseminated intravascular coagulation and multi-organ system failure. In the last few years, studies in rodents have shown that administration of low concentrations of carbon monoxide ( CO) exerts potent therapeutic effects in a variety of diseases/disorders. In this study, we have administered CO ( one our pretreatment at 250 ppm) in a clinically relevant, well-characterized model of LPS-induced acute lung injury in pigs. Pretreatment only with inhaled CO significantly ameliorated several of the acute pathological changes induced by endotoxic shock. In terms of lung physiology, CO pretreatment corrected the LPS-induced changes in resistance and compliance and improved the derangement in pulmonary gas exchange. In terms of coagulation and inflammation, CO reduced the development of disseminated intravascular coagulation and completely suppressed serum levels of the proinflammatory IL-1 beta in response to LPS, while augmenting the anti-inflammatory cytokine IL-10. Moreover, the effects of CO blunted the deterioration of kidney and liver function, suggesting a beneficial effect in terms of end organ damage associated with endotoxic shock. Lastly, CO pretreatment prevents LPS-induced ICAM expression on lung endothelium and inhibits leukocyte marginalization on lung parenchyma. |
| Databáze: | OpenAIRE |
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