Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
| Autor: | Jin, X., Bauer, D. E., Tuttleton, S. E., Lewin, S., Gettie, A., Blanchard, J., Irwin, C. E., Safrit, J. T., Mittler, J., Weinberger, L., Kostrikis, Leontios G., Zhang, L., Perelson, A. S., Ho, David D. |
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| Přispěvatelé: | Kostrikis, Leontios G. [0000-0002-5340-7109] |
| Rok vydání: | 1999 |
| Předmět: |
CD4-Positive T-Lymphocytes
macaca Simian Acquired Immunodeficiency Syndrome animal cell CD8-Positive T-Lymphocytes Virus Replication medicine.disease_cause Medical and Health Sciences virus inhibition 0302 clinical medicine Immunology and Allergy Cytotoxic T cell virus replication retrovirus infection 0303 health sciences education.field_of_study biology macaque article Simian immunodeficiency virus Articles cytotoxic T lymphocyte 3. Good health priority journal HIV/AIDS Antibody Infection Viral load Macaque OKT8 simian immunodeficiency virus animal experiment Immunology Population Viremia cellular immunity 03 medical and health sciences medicine Animals controlled study education 030304 developmental biology viremia nonhuman Cytotoxic T lymphocyte animal model virus load medicine.disease Macaca mulatta Virology Viral replication biology.protein Immunization CD8 030215 immunology |
| Zdroj: | Journal of Experimental Medicine J.Exp.Med. The Journal of Experimental Medicine The Journal of experimental medicine, vol 189, iss 6 |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.189.6.991 |
| Popis: | To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of CD8 cells in peripheral blood in six infected Macaca mulatta treated with OKT8F. The apparent CD8 depletion started 1 h after antibody administration, and low CD8 levels were maintained until day 8. An increase in plasma viremia of one to three orders of magnitude was observed in five of the six macaques. The injection of a control antibody to an infected macaque did not induce a sustained viral load increase, nor did it significantly reduce the number of CD8+ T cells. These results demonstrate that CD8 cells play a crucial role in suppressing SIV replication in vivo. 189 991 998 Cited By :1106 |
| Databáze: | OpenAIRE |
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