Longitudinal Impact of Physical Activity on Brain Pulsatility Index and Cognition in Older Adults with Cardiovascular Risk Factors: A NIRS Study
| Autor: | Sarah Fraser, Ali Kassab, Thomas Vincent, Christine Gagnon, Louis Bherer, Hanieh Mohammadi, Frédéric Lesage, Anil Nigam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
cardiovascular risk factors
medicine.medical_specialty cerebral pulsatility longitudinal near-infrared spectroscopy Cardiovascular risk factors Physical activity Hemodynamics physical activity Neurosciences. Biological psychiatry. Neuropsychiatry 030204 cardiovascular system & hematology Pulsatility index Article 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation medicine Cognitive decline business.industry General Neuroscience Cognition Executive functions medicine.anatomical_structure business 030217 neurology & neurosurgery RC321-571 Motor cortex |
| Zdroj: | Brain Sciences Volume 11 Issue 6 Brain Sciences, Vol 11, Iss 730, p 730 (2021) |
| ISSN: | 2076-3425 |
| DOI: | 10.3390/brainsci11060730 |
| Popis: | Recent studies have shown that optical indices of cerebral pulsatility, including cerebral pulse amplitude, are linked to cerebrovascular health. A chronically higher cerebral pulsatility is associated with cognitive decline. Although it is widely known that regular physical activity improves cognitive functions, little is known about the association between physical activity and the optical index of cerebral pulsatility. This study assessed the impact of 12 months of regular physical activity on the changes in the optical index of cerebral pulsatility and explored its association with cognition. A total of 19 older adults (aged 59–79 years) with cardiovascular risk factors (CVRF) completed the study. Low-intensity, short-duration walking as a brief cardiovascular challenge was used to study the impact of regular physical activity on post-walking changes in cerebral pulsatility index. The participants walked on a gym track while a near-infrared spectroscopy (NIRS) device recorded hemodynamics data from the frontal and motor cortex subregions. Our data indicated that 12 months of physical activity was associated with lower global cerebral pulse amplitude, which was associated with higher cognitive scores in executive functions. Further, the global cerebral pulsatility index was reduced after short-duration walking, and this reduction was greater after 12 months of regular physical activity compared with the baseline. This may be an indication of improvement in cerebrovascular response to the cardiovascular challenge after regular physical activity. This study suggests that 12 months of physical activity may support cognitive functions through improving cerebral pulsatility in older adults with CVRF. |
| Databáze: | OpenAIRE |
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