| Autor: |
Vijayasaradhi Setaluri, Michelle E. Kimple, Jaclyn A. Wisinski, B. Jack Longley, Laura Block, Kirthana Prabhakar, Edgardo Castro-Pérez, Carlos I. Rodríguez |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1541-7786.22512109.v1 |
| Popis: |
Fig. S1. Characterization of melanoma tumors and tumor derived cells of BrafCA/Pten-/- mouse. Fig. S2. Status of cAMP signaling in metastatic melanoma. Fig S3. Effect of cAMP inducing agent on human metastatic melanoma cell lines. Fig. S4. Survival of metastatic melanoma cells to MAPK pathway inhibition and elevation of [cAMP]. Fig. S5. Effect of cAMP elevation in AKT and mTOR signaling in human melanoma cells. Fig. S6. Effect of PKA inhibition by H89 on sensitivity of melanoma cells to BRAF(V600E) inhibitor PLX4032. Fig. S7. Effect of CREB knockdown and cAMP elevation in human metastatic melanoma cells. Fig. S8. Expression and the role of EPAC and RAP1 in human melanoma cells. Fig. S9. Role of EPAC in melanoma survival and MAPK pathway inhibition. Fig. S10. Effect of EPAC inhibition on MITF and pigmentation related proteins in human melanoma cells. Fig. S11. RAP1B overexpression in human melanoma cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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