Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China
| Autor: | Roberta M. Ray, Johanna W. Lampe, Dao Li Gao, Jackilen Shannon, Peggy L. Porter, David B. Thomas, Wenjin Li, Kristiina Wähälä, Ming Gang Lin, Cara L. Frankenfeld, Helge Stalsberg, Charlotte Atkinson |
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| Přispěvatelé: | University of Helsinki, Department of Chemistry, Kristiina Wähälä-Hase / Principal Investigator, Synthesis and Analysis |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Fibrocystic Breast Disease Endocrinology Diabetes and Metabolism Physiology SOY ISOFLAVONE INTAKE equol chemistry.chemical_compound 0302 clinical medicine Endocrinology Breast cancer Odds Ratio Medicine MAMMOGRAPHIC DENSITY DIETARY ISOFLAVONE Nutrition and Dietetics food and beverages Equol Middle Aged Isoflavones PHYTOESTROGENS Isoflavone 3. Good health PROSTATE-CANCER PHYTO-ESTROGENS POSTMENOPAUSAL WOMEN PREMENOPAUSAL WOMEN 030220 oncology & carcinogenesis Daidzein Fibrocystic changes in the breast Nested case-control study Female NUTRITION women daidzein isoflavone Adult China medicine.medical_specialty 3122 Cancers Breast Neoplasms Article 03 medical and health sciences breast cancer Internal medicine Humans Women fibrocystic changes in the breast 030109 nutrition & dietetics Fibrocystic breasts business.industry Breast Self-Examination nested case–control study medicine.disease chemistry Case-Control Studies RISK-FACTORS Phytoestrogens business |
| Zdroj: | Atkinson, C, Ray, R M, Li, W, Lin, M-G, Gao, D L, Shannon, J, Stalsberg, H, Porter, P L, Frankenfeld, C L, Wähälä, K, Thomas, D B & Lampe, J W 2016, ' Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China ', Nutrition Research, vol. 36, no. 8, pp. 863-871 . https://doi.org/10.1016/j.nutres.2016.03.008 |
| DOI: | 10.1016/j.nutres.2016.03.008 |
| Popis: | Equol (a bacterial metabolite of the soy isoflavone daidzein) is produced by 30% to 50% of humans and may be associated with health outcomes. We hypothesized that plasma equol would be inversely associated with risks of fibrocystic breast conditions (FBC) and breast cancer (BC). Plasma from women in a breast self-examination trial in Shanghai with BC (n = 269) or FBC (n = 443), and age-matched controls (n = 1027) was analyzed for isoflavones. Equol was grouped into categories (= 45 nmol/L) and, among women with daidzein >= 20 nmol/L, the log(10) equol:daidzein ratio was grouped into tertiles. Where available, non-cancerous tissue (NCT) adjacent to the carcinomas from women with BC were classified as non-proliferative or proliferative (n = 130 and 172, respectively). The lesions from women with FBC were similarly classified (n = 99 and 92, respectively). Odds ratios (OR) and 95% confidence intervals (CI) were calculated across equol categories and tertiles of log(10) equol:daidzein ratio. Equol categories were not associated with FBC or BC >.05). For log(10) equol:daidzein, compared to controls there were positive associations in the mid tertile for proliferative FBC (OR 2.06, 95% CI 1.08-3.93), BC with proliferative NCT (OR 2.95, 95% CI 1.37-6.35), and all BC regardless of histology (OR 2.37, 95% CI 1.43-3.95). However, trends in ORs with increasing plasma equol values or equol:daidzein ratios were not observed (P >.05). The results of this study do not provide evidence that equol plays a role in the etiology of these breast conditions. However, further work is needed to confirm or refute this conclusion. (C) 2016 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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