Supplementary Figures from STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma

Autor: Masahiko Nishiyama, Carol Prives, Jun'ichi Tamura, Tetsunari Oyama, Kimihiro Shimizu, Yoichi Ohtaki, Takehiko Yokobori, Shinji Yoshiyama, Reika Iwakawa-Kawabata, Ikuko Horikoshi, Michiru Fujieda, Kyoichi Kaira, Susumu Rokudai, Yukihiro Otaka
Rok vydání: 2023
DOI: 10.1158/1078-0432.22462913
Popis: Supplementary Figure 1. STXBP4 expression is correlated with poor prognosis in patients with tumors expressing high ΔNp63 levels. Supplementary Figure 2. Causal networks associated with STXBP4 expression in lung SCC. Supplementary Figure 3. Depletion of PDGFRα suppresses the growth of lung SCC. Supplementary Figure 4. PDGFRA mRNA was significantly correlated with STXBP4 in the gene expression profiles of lung SCC patients. Supplementary Figure 5. PDGFRA expression is upregulated in STXBP4-transduced lung SCC cells. Supplementary Figure 6. STXBP4-depletion inhibits SCC tumorigenesis and modulates PDGF signaling in vivo. Supplementary Figure 7. STXBP4 promotes tumorigenesis through PDGFRA in lung SCC.
Databáze: OpenAIRE