Coiling of the Internal Carotid Artery is Associated with Hypertension in Patients Suspected of Stroke
| Autor: | Richard A.P. Takx, Jan Willem Dankbaar, Dust investigators, Birgitta K. Velthuis, Pim A. de Jong, Josephus L.M. Van Rooij |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Tortuosity 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine.artery Humans Medicine Radiology Nuclear Medicine and imaging Coiling Stroke Dolichoarteriopathy Aged Neuroradiology Aged 80 and over medicine.diagnostic_test business.industry Odds ratio Middle Aged medicine.disease United States Confidence interval Case-Control Studies Hypertension Angiography Cardiology Etiology Female Original Article Neurology (clinical) Internal carotid artery business Carotid Artery Internal 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neuroradiology |
| ISSN: | 1869-1447 1869-1439 |
| DOI: | 10.1007/s00062-020-00892-4 |
| Popis: | Purpose The etiology of coiling (i.e. severe elongation) of the extracranial part of the internal carotid artery (ICA) is poorly understood with the proposed etiology being congenital, atherosclerotic or hypertension. The objective was to investigate the association of coiling with hypertension, carotid artery atherosclerosis and other cardiovascular risk factors. Methods A case control study was performed in patients suspected of stroke, with (cases) or without (controls) coiling of the ICA determined on compute tomography angiography (CTA). Baseline characteristics included age, gender, hypertension, diabetes, smoking and hypercholesterolemia. Coiling of the ICA and atherosclerotic plaque at the carotid bifurcation were assessed on CTA. Logistic regression analyses were conducted. Results Coiling was identified in 108 patients with a median age of 71 years. Cases were compared with 256 controls with a median age of 69 years. Hypertension was present in 63% of the patients with coiling compared to 51% in the control group. Univariable analysis showed that hypertension was significantly associated with coiling, with an odds ratio of 1.65 (95% confidence interval (CI) 1.04–2.61, p = 0.034). Multivariable analysis corrected for age and sex resulted in an odds ratio of 1.71 (95% CI 1.05–2.80, p = 0.032), while correcting for atherosclerotic plaque at the bifurcation yielded an odds ratio of 1.63 (95% CI 1.00–2.66, p = 0.049). Age and atherosclerotic plaque were not significantly associated with coiling. Conclusion The main finding of this study was the significant association of hypertension with coiling of the ICA and the absence of an association with age, plaques and atherosclerotic risk factors other than hypertension. |
| Databáze: | OpenAIRE |
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