Neurophysiologic and intellectual evaluation of beta-thalassemia patients
| Autor: | Miranda Athanassiou-Metaxa, Nikos Gompakis, Vasilios Perifanis, Eleftherios E. Kontopoulos, Dimitrios I. Zafeiriou, Aphroditi Koussi, Marina Economou |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty genetic structures Adolescent Intelligence Neurophysiology Siderophores Deferoxamine Neuropsychological Tests Nerve conduction velocity Developmental Neuroscience medicine Humans Prospective Studies Young adult Prospective cohort study Child Evoked Potentials Wechsler Intelligence Scale for Children Intelligence Tests Analysis of Variance Intelligence quotient beta-Thalassemia Wechsler Adult Intelligence Scale Beta thalassemia General Medicine medicine.disease Surgery Somatosensory evoked potential Pediatrics Perinatology and Child Health Female Neurology (clinical) Psychology |
| Zdroj: | Braindevelopment. 28(1) |
| ISSN: | 0387-7604 |
| Popis: | In order to detect involvement of the central and peripheral nervous system in beta-thalassemic patients, 32 children and young adults (mean age 14.5±6.4 years) participated in a systematic neurophysiologic and intellectual prospective study. All patients were in a regular transfusion program, receiving subcutaneous desferrioxamine chelation and maintaining a mean serum ferritin level of 2,101.56±986.32 ng/ml. Study patients underwent neurophysiologic evaluation consisting of brainstem auditory, visual and somatosensory evoked potential examination (BAEP, VEP, SEP) as well as motor and sensory nerve conduction velocity studies (MCV, SCV). Additionally, the verbal, performance and total IQ were assessed in patients under 16 years of age using the Weschler Intelligence Scale for Children (WISC-III). The incidence of abnormal BAEP, VEP, SEP and NCVs was 0, 3.12, 3.12 and 18.75%, respectively, findings comparative to or better than previously reported. On the contrary, the prevalence of abnormal total IQ score was considerably high (36.4%), not correlating, however, to any of the parameters assessed (age, sex, ferritin level, BAEP, VEP, SEP, NCV). Factors associated with chronic illness, rather than the disease per se, could play a potential role in the development of cognitive dysfunction in beta-thalassemia patients. |
| Databáze: | OpenAIRE |
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