Effect of Preoperative Dexmedetomidine on Prevalence of Postoperative Cognitive Dysfunction in Elderly Patients Candidate for Orthopedic Surgery under General Anesthesia
| Autor: | Mona Haji Aghajani, Mohammad Reza Ghodraty, Alireza Pournajafian, Azadeh Emami, Ali Khatibi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 medicine.disease Atomic and Molecular Physics and Optics Postoperative Cognitive Dysfunction lcsh:RD78.3-87.3 Orthopedics lcsh:Anesthesiology Anesthesia Orthopedic surgery medicine Electrical and Electronic Engineering Dexmedetomidine business Postoperative cognitive dysfunction medicine.drug |
| Zdroj: | Archives of Anesthesia and Critical Care, Vol 6, Iss 4 (2020) |
| ISSN: | 2423-5849 |
| DOI: | 10.18502/aacc.v6i4.4629 |
| Popis: | Background: Postoperative cognitive dysfunction (POCD) is amongst the most critical complications after surgery. This study shows the effect of dexmedetomidine on the prevalence of postoperative cognitive impairment. Methods: In this double-blinded clinical trial study, patients aged 60-80 years undergoing pelvic and femoral orthopedic surgery were randomly assigned in one of the two groups of the course, i.e., Dexmedetomidine (DEX) or normal saline (NS). We infuse One hour before anesthesia, one µg/kg dexmedetomidine in the group (DEX), and the same volume of normal saline (NS). Mini-Mental State Examination test (MMSE) was applied to evaluate the patients' cognitive condition, One day before the surgery, 24 and 72 hours after the surgery. Results: There was no significant difference between the two groups in terms of age, sex, duration of anesthesia, duration of surgery, and the amount of bleeding during operation (P>0.0). The postoperative hematocrit level was lower than the preoperative level in the group (DEX) (P0.05). Conclusion: Dexmedetomidine infused before surgery has no preventive effect on POCD in elderly patients undergoing pelvic and femoral orthopedic surgery under general anesthesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|