Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome
| Autor: | Filomena Argenzio, Antonio Grella, Caterina Aurilio, Gianfranco Di Renzo, Salvatore Amoroso, Aldo Quattrone, Lucio Annunziato |
|---|---|
| Přispěvatelé: | Annunziato, L, Amoroso, S, DI RENZO, G, Argenzio, Filomena, Aurilio, Caterina, Grella, Antonio, Quattrone, A., Annunziato, Lucio, S., Amoroso, DI RENZO, GIANFRANCO MARIA LUIGI, F., Argenzio, C., Aurilio, A., Grella, A., Quattrone |
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment media_common.quotation_subject Dopamine Stimulation General Biochemistry Genetics and Molecular Biology Receptors Dopamine Internal medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics media_common Chemotherapy Ethanol business.industry Addiction Antagonist General Medicine Growth hormone secretion Domperidone Stimulation Chemical Substance Withdrawal Syndrome Endocrinology Dopamine receptor Growth Hormone Female business Human medicine.drug |
| Zdroj: | Life sciences. 33(26) |
| ISSN: | 0024-3205 |
| Popis: | In humans the release of growth hormone (GH) elicited by dopamine (DA) and DA agonists may represent a reliable model to assess change in sensitivity of DA receptors. We now report that in chronic alcoholics, 4–7 days after the suspension of alcohol consumption, the increase of GH response to DA infusion was higher than that seen in non alcoholic volunteers. The specificity of this GH response to DA administration was demonstrated by the use of domperidone, a novel peripheral antagonist of DA receptors. These results suggest the development of hyper-responsiveness of DA receptors involved in the control of GH secretion in chronic alcoholics during the later phases of the “withdrawal syndrome”. |
| Databáze: | OpenAIRE |
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