Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2Cl

Autor:	Shiro Ebata, Yoshiaki Nakao, Sensuke Ogoshi, Masashi Ikawa, Tamejiro Hiyama, Akira Yada
Rok vydání:	2008
Předmět:	Nickel Colloid and Surface Chemistry chemistry Intramolecular force chemistry.chemical_element Organic chemistry General Chemistry Biochemistry Combinatorial chemistry Catalysis Stereocenter Quaternary carbon
Zdroj:	Journal of the American Chemical Society. 130(39)
ISSN:	1520-5126
Popis:	A catalyst system derived from nickel and cocatalytic AlMe2Cl effects the intramolecular arylcyanation of alkenes. The reaction takes place in an exclusive exo-dig manner to give a wide range of nitriles having a benzylic quaternary carbon in good yields. Detailed investigations are described on the scope and mechanism as well as preliminary results on the asymmetric version of the reaction to provide novel access to chiral quaternary stereocenters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a13073a9586183aa09237343d70ff1d https://pubmed.ncbi.nlm.nih.gov/18778055 Zobrazit plný text záznamu