Decreased Anti-Inflammatory Responses to Vitamin D in Neonatal Neutrophils
| Autor: | Daniel S. Hirsch, Meera Joshi-Kale, Barry Weinberger, Anna M. Vetrano, Faith E. Archer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Article Subject Neutrophils Immunology Anti-Inflammatory Agents Inflammation Biology Calcitriol receptor Models Biological 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030225 pediatrics Internal medicine Gene expression medicine Vitamin D and neurology lcsh:Pathology Macrophage Humans Vitamin D Chemokine CCL4 030304 developmental biology Calcifediol Regulation of gene expression 0303 health sciences Infant Newborn Cell Biology Hydrogen Peroxide 3. Good health Respiratory burst Endocrinology chemistry Gene Expression Regulation Female medicine.symptom Research Article lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2011 (2011) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Neutrophil activity is prolonged in newborns, suggesting decreased exposure and/or responses to immunosuppressive modulators, such as 1,25-hydroxyvitamin D3(1,25-vit D3). We hypothesized that 1,25-vit D3suppresses neutrophil activation and that this response is impaired in newborns. Consistent with this, 1,25-vit D3decreased LPS-induced expression of macrophage inflammatory protein-1βand VEGF in adult, but not neonatal, neutrophils. Expression of vitamin D receptor (VDR) and 25-hydroxyvitamin D3-1α-hydroxylase was reduced in neonatal, relative to adult neutrophils. Moreover, 1,25-vit D3induced VDR gene expression in activated adult, but not neonatal, neutrophils. 1,25-vit D3also suppressed expression of cyclooxygenase-2 and induced expression of 5-lipoxygenase in LPS-exposed adult neutrophils, while neonatal cells were not affected. 1,25-vit D3had no effect on respiratory burst in either adult or neonatal cells. Anti-inflammatory activity of vitamin D is impaired in neonatal neutrophils, and this may be due to decreased expression of VDR and 1α-hydroxylase. Insensitivity to 1,25-vit D3may contribute to chronic inflammation in neonates. |
| Databáze: | OpenAIRE |
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