Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa
| Autor: | Haiqun Cao, Ya-Jing Deng, Jin-Jing Xiao, Wen-Zhe Feng, Yan-Hong Shi, Dong Wei, Yu-Ying Liu, Min Liao |
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| Rok vydání: | 2021 |
| Předmět: |
Absorption (skin)
Gut flora digestive system 01 natural sciences Intestinal absorption Analytical Chemistry Neonicotinoids 0404 agricultural biotechnology Humans Food science Intestinal Mucosa Pesticides Chaenomeles speciosa Rosaceae Bacteria biology Pesticide residue Chemistry digestive oral and skin physiology 010401 analytical chemistry Organothiophosphorus Compounds 04 agricultural and veterinary sciences General Medicine Metabolism Pesticide Nitro Compounds biology.organism_classification 040401 food science Gastrointestinal Microbiome 0104 chemical sciences Caco-2 Cells Thiamethoxam Lactobacillus plantarum Food Science |
| Zdroj: | Food Chemistry. 339:127985 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2020.127985 |
| Popis: | There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal Microbial Ecosystem for the determination of pesticide residue bioaccessibility in Chaenomeles speciosa, and a Caco-2 cell model of human intestinal absorption. Results showed that gut microbiota played a dual role based their effects on contaminant release and metabolism in the bioaccessibility assay, and Lactobacillus plantarum was one of key bacterial species in the gut microbiota that influenced pesticide stability significantly. The addition of L. plantarum to the system reduced the relative amounts (by 11.40-86.51%) of six pesticides. The interaction between the food matrix and human gut microbiota led to different absorption rates, and the barrier effects increased with an increase in incubation time. |
| Databáze: | OpenAIRE |
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