Tobacco smoking and the risk of diverticular disease - a systematic review and meta-analysis of prospective studies

Autor: Dagfinn Aune, Michael F. Leitzmann, Serena Tonstad, Abhijit Sen, Lars J. Vatten, Teresa Norat
Rok vydání: 2016
Předmět:
Male
diverticular disease
POPULATION-BASED COHORT
0302 clinical medicine
cohort studies
Risk Factors
IMMUNE-RESPONSE
Prospective Studies
Prospective cohort study
Aged
80 and over
Incidence (epidemiology)
Incidence
Gastroenterology
Middle Aged
CANCER
Diverticulosis
030220 oncology & carcinogenesis
Meta-analysis
Diverticular disease
030211 gastroenterology & hepatology
LIFE-STYLE
Female
Life Sciences & Biomedicine
Cohort study
Adult
medicine.medical_specialty
Perforation (oil well)
DOSE-RESPONSE DATA
smoking
03 medical and health sciences
INTESTINAL MICROBIOTA
Internal medicine
COLON
Tobacco
medicine
Tobacco Smoking
Humans
Diverticulitis
Aged
Diverticular Diseases
Science & Technology
Gastroenterology & Hepatology
business.industry
1103 Clinical Sciences
NATURAL-HISTORY
medicine.disease
Surgery
meta-analysis
BODY-MASS INDEX
Diverticulum
Relative risk
CIGARETTE-SMOKING
business
Zdroj: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 19(7)
ISSN: 1463-1318
Popis: Aim This systematic review and meta-analysis aimed to clarify whether tobacco smoking is associated with an increased risk of diverticular disease. Methods PubMed and Embase databases were searched for studies of smoking and diverticular disease up to February 19, 2016. Prospective studies that reported adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of diverticular disease associated with current, r or previous smoking were included. Summary RRs were estimated using a random effects model. Results We identified five prospective studies which comprised 6,076 incident diverticular disease (diverticulosis and diverticulitis) cases, 385,291 participants and three studies with 1,118 cases of complications related to diverticular disease (abscess or perforation) among 292,965 participants that could be included in the meta-analysis. The summary RR for incident diverticular disease was 1.36 (95% CI: 1.15-1.61, I2=84%, n=4) for current smokers, 1.17 (95% CI: 1.05-1.31, I2=49%, n=4) for former smokers and 1.33 (95% CI: 1.22-1.46, I2=55%, n=7) for ever smokers. The summary relative risk was 1.11 (95% CI: 0.99-1.25,I2=82%, n=4) per 10 cigarettes per day. Although there was some indication of nonlinearity there was a dose-dependent positive association with increasing number of cigarettes smoked per day. There was some evidence that smoking also increases the risk of diverticular disease complications, but the number of studies was small. Conclusion The current meta-analysis provides evidence that tobacco smoking is associated with an increased incidence of of diverticular disease and related complications. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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