Tobacco smoking and the risk of diverticular disease - a systematic review and meta-analysis of prospective studies
Autor: | Dagfinn Aune, Michael F. Leitzmann, Serena Tonstad, Abhijit Sen, Lars J. Vatten, Teresa Norat |
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Rok vydání: | 2016 |
Předmět: |
Male
diverticular disease POPULATION-BASED COHORT 0302 clinical medicine cohort studies Risk Factors IMMUNE-RESPONSE Prospective Studies Prospective cohort study Aged 80 and over Incidence (epidemiology) Incidence Gastroenterology Middle Aged CANCER Diverticulosis 030220 oncology & carcinogenesis Meta-analysis Diverticular disease 030211 gastroenterology & hepatology LIFE-STYLE Female Life Sciences & Biomedicine Cohort study Adult medicine.medical_specialty Perforation (oil well) DOSE-RESPONSE DATA smoking 03 medical and health sciences INTESTINAL MICROBIOTA Internal medicine COLON Tobacco medicine Tobacco Smoking Humans Diverticulitis Aged Diverticular Diseases Science & Technology Gastroenterology & Hepatology business.industry 1103 Clinical Sciences NATURAL-HISTORY medicine.disease Surgery meta-analysis BODY-MASS INDEX Diverticulum Relative risk CIGARETTE-SMOKING business |
Zdroj: | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 19(7) |
ISSN: | 1463-1318 |
Popis: | Aim This systematic review and meta-analysis aimed to clarify whether tobacco smoking is associated with an increased risk of diverticular disease. Methods PubMed and Embase databases were searched for studies of smoking and diverticular disease up to February 19, 2016. Prospective studies that reported adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of diverticular disease associated with current, r or previous smoking were included. Summary RRs were estimated using a random effects model. Results We identified five prospective studies which comprised 6,076 incident diverticular disease (diverticulosis and diverticulitis) cases, 385,291 participants and three studies with 1,118 cases of complications related to diverticular disease (abscess or perforation) among 292,965 participants that could be included in the meta-analysis. The summary RR for incident diverticular disease was 1.36 (95% CI: 1.15-1.61, I2=84%, n=4) for current smokers, 1.17 (95% CI: 1.05-1.31, I2=49%, n=4) for former smokers and 1.33 (95% CI: 1.22-1.46, I2=55%, n=7) for ever smokers. The summary relative risk was 1.11 (95% CI: 0.99-1.25,I2=82%, n=4) per 10 cigarettes per day. Although there was some indication of nonlinearity there was a dose-dependent positive association with increasing number of cigarettes smoked per day. There was some evidence that smoking also increases the risk of diverticular disease complications, but the number of studies was small. Conclusion The current meta-analysis provides evidence that tobacco smoking is associated with an increased incidence of of diverticular disease and related complications. This article is protected by copyright. All rights reserved. |
Databáze: | OpenAIRE |
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