Summary of animal models of myelodysplastic syndrome
| Autor: | Mengyuan Li, Ran Gao, Lin Cao, Wenlong Zhang, Xingjiu Yang, Weisha Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Candidate gene
Medicine (General) Transplantation Heterologous Clone (cell biology) Reviews Review Bioinformatics Pathogenesis Mice R5-920 hemic and lymphatic diseases medicine Animals Humans Zebrafish Curative effect Acute leukemia Leukemia business.industry myelodysplastic syndrome (MDS) General Medicine medicine.disease Phenotype animal models Rats Haematopoiesis Leukemia Myeloid Acute Myelodysplastic Syndromes Models Animal business Genetic Engineering |
| Zdroj: | Animal Models and Experimental Medicine, Vol 4, Iss 1, Pp 71-76 (2021) Animal Models and Experimental Medicine |
| ISSN: | 2576-2095 |
| Popis: | Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long‐term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with similar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS phenotype. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS). Animal models of myelodysplastic syndrome (MDS). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text