Mitochondrial Pathophysiology on Chronic Kidney Disease
| Autor: | Pedro Fontes Oliveira, Anabela Soares Rodrigues, Marco G. Alves, Patricia Braga |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Epithelial-Mesenchymal Transition
QH301-705.5 Organic Chemistry chronic kidney disease (CKD) General Medicine electron transport phosphorylation (ETC) impairment urologic and male genital diseases Fibrosis Catalysis Computer Science Applications Mitochondria Inorganic Chemistry epithelial-mesenchymal transition (EMT) Chemistry Animals Humans Biology (General) Physical and Theoretical Chemistry Renal Insufficiency Chronic oxidative stress (OS) QD1-999 Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences, Vol 23, Iss 1776, p 1776 (2022) |
| ISSN: | 1422-0067 |
| Popis: | In healthy kidneys, interstitial fibroblasts are responsible for the maintenance of renal architecture. Progressive interstitial fibrosis is thought to be a common pathway for chronic kidney diseases (CKD). Diabetes is one of the boosters of CKD. There is no effective treatment to improve kidney function in CKD patients. The kidney is a highly demanding organ, rich in redox reactions occurring in mitochondria, making it particularly vulnerable to oxidative stress (OS). A dysregulation in OS leads to an impairment of the Electron transport chain (ETC). Gene deficiencies in the ETC are closely related to the development of kidney disease, providing evidence that mitochondria integrity is a key player in the early detection of CKD. The development of novel CKD therapies is needed since current methods of treatment are ineffective. Antioxidant targeted therapies and metabolic approaches revealed promising results to delay the progression of some markers associated with kidney disease. Herein, we discuss the role and possible origin of fibroblasts and the possible potentiators of CKD. We will focus on the important features of mitochondria in renal cell function and discuss their role in kidney disease progression. We also discuss the potential of antioxidants and pharmacologic agents to delay kidney disease progression. |
| Databáze: | OpenAIRE |
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