Upper eyelid Merkel cell carcinoma treated with neoadjuvant chemotherapy and surgical excision
| Autor: | Vincenzo Panasiti, Vito Toto, Valeria Devirgiliis, Paolo Persichetti, Alfredo Colapietra, Mario Alessandri-Bonetti, Bruno Vincenzi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Case Report 03 medical and health sciences 0302 clinical medicine Carcinoma Medicine 030223 otorhinolaryngology Neoadjuvant therapy Skin neoplasm Skin Neoplasm Merkel cell business.industry Merkel cell carcinoma 030206 dentistry Eyelid Neoplasm medicine.disease Surgery medicine.anatomical_structure Otorhinolaryngology Chalazion Eyelid business Eyelid neoplasm |
| Zdroj: | Archives of Craniofacial Surgery |
| ISSN: | 2287-5603 2287-1152 |
| Popis: | Merkel cell carcinoma is a rare cutaneous carcinoma, featured by an aggressive clinical course and a mortality rate of 28% at 2 years. A 71-year-old female was affected by a 4.1-cm-wide locally advanced Merkel cell carcinoma of the upper eyelid, previously misdiagnosed as chalazion, with involvement of the extraocular muscles. Although the tumor showed a macroscopic spontaneous regression in size after the incisional biopsy, the mass was treated with neoadjuvant chemotherapy and surgical excision. Good functional and aesthetic result with preservation of the eyeball and absence of tumor recurrence were achieved at 3-year follow-up. In our experience, the combination of the inflammatory cascade due to the incisional biopsy and neoadjuvant chemotherapy led to the regression of a locally advanced large Merkel cell carcinoma of the eyelid. |
| Databáze: | OpenAIRE |
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