Effect of donor type on volume of blood transfusions required after allogeneic hematopoietic cell transplantation
| Autor: | Ayumu Ito, Yuki Minakawa, Ryuzaburo Ohtake, Minoru Kojima, Yoshihiro Inamoto, Takuhiro Yamaguchi, Tuneaki Hirakawa, Takahiro Fukuda, Kimihiko Kawamura, Moemi Kasane, Jun Aoki, Misato Tsubokura, Wataru Takeda, Sung-Won Kim, Nao Iwashita, Saori Nakabayashi, Minoko Takanashi, Saiko Kurosawa, Yukiko Nishioka, Takashi Tanaka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Erythrocyte Indices Male medicine.medical_specialty Blood transfusion Time Factors Adolescent medicine.medical_treatment Clinical Decision-Making ABO Blood-Group System 03 medical and health sciences Young Adult 0302 clinical medicine Blood product Internal medicine medicine Humans Transplantation Homologous Platelet Blood Transfusion Aged Postoperative Care Hematology Hematopoietic cell business.industry Platelet Count Hematopoietic Stem Cell Transplantation Disease Management Middle Aged Tissue Donors Transplantation Red blood cell Platelet transfusion medicine.anatomical_structure Blood Grouping and Crossmatching 030220 oncology & carcinogenesis Female business Biomarkers 030215 immunology |
| Zdroj: | International journal of hematology. 113(4) |
| ISSN: | 1865-3774 |
| Popis: | We reviewed blood product use in 729 consecutive allogeneic hematopoietic cell transplantation (allo-HCT) recipients at our center to assess the volume of red blood cells (RBCs) and platelets required after allo-HCT. The median number of bags required by day 30 was 4 for RBCs (range 0-22) and 9.5 for platelets (0-53). Multivariate analysis showed that related peripheral blood stem cell transplantation (PBSCT) required a significantly lower RBC transfusion volume by day 30 compared to unrelated bone marrow transplantation (UBMT). PBSCT from haplo-identical related donors and cord blood transplantation (CBT) required a significantly greater RBC transfusion volume. For platelet transfusion, related and unrelated PBSCT required a significantly lower volume than UBMT, and CBT a greater volume. Other factors independently associated with greater RBC transfusion volume were male sex, disease status other than complete remission, and major ABO mismatch. For platelet transfusion, these were male sex, disease status, and HCT-specific comorbidity index of 1. Although the burden of blood transfusions may not be the most important factor when choosing a donor type, our findings may provide a foundation for nationwide strategies to prepare blood products and inform aspects of national healthcare expenditures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink