Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones
| Autor: | Wkw Seto, W. S. Ng, D. N. C. Tsang, T. L. Que, Wing-Cheong Yam, Pak-Leung Ho, T. K. Ng |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Microbiology (medical)
Microbial Sensitivity Tests Drug resistance medicine.disease_cause Microbiology Anti-Infective Agents Bacterial Proteins Levofloxacin Streptococcus pneumoniae medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology biology Biological Transport Drug Resistance Microbial biochemical phenomena metabolism and nutrition bacterial infections and mycoses Streptococcaceae biology.organism_classification Ciprofloxacin Phenotype Infectious Diseases Amino Acid Substitution Mutation Efflux Bacteria Fluoroquinolones medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 47:655-658 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/47.5.655 |
| Popis: | Ciprofloxacin-susceptible (n = 7) and -resistant (MIC >or=4 mg/L) (n = 15) clinical isolates of Streptococcus pneumoniae from diverse sources in Hong Kong were studied for target site modifications and efflux phenotype. Reserpine-inhibited efflux of ciprofloxacin and/or levofloxacin was common in both susceptible and non-susceptible isolates. The ParC substitutions K137N and/or S79F or Y were associated with increased ciprofloxacin MICS. The GyrA substitution S81F was only found in isolates with full resistance to ciprofloxacin (MIC >or=16 mg/L) and levofloxacin (MIC >or=8 mg/L). Among clinical isolates of S. pneumoniae, accumulation of target site mutations in strains with an efflux mechanism was associated with increasing MICs of fluoroquinolones. |
| Databáze: | OpenAIRE |
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