Total Synthesis of the Biscarbazole Alkaloids Murrafoline A-D by a Domino Sonogashira Coupling/Claisen Rearrangement/Electrocyclization Reaction

Autor:	V. Pavan Kumar, Konstanze K. Gruner, Olga Kataeva, Hans-Joachim Knölker
Rok vydání:	2013
Předmět:	Molecular Structure Stereochemistry Carbazoles Sonogashira coupling chemistry.chemical_element Total synthesis Stereoisomerism General Chemistry Crystal structure General Medicine Crystallography X-Ray Catalysis Domino Claisen rearrangement Alkaloids Cascade reaction chemistry Cyclization Palladium
Zdroj:	Angewandte Chemie. 125:11279-11283
ISSN:	0044-8249
Popis:	Why take things one step at a time? Aryl-pyran-linked biscarbazole alkaloids of the murrafoline group (see crystal structure of murrafoline A; dark gray: C, red: O, blue: N) were accessed readily by a novel domino reaction sequence involving Sonogashira coupling, a Claisen rearrangement, and electrocyclization. The one-pot procedure enables the straightforward synthesis of these structurally challenging alkaloids in only a few steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a04b35ab7d021874a53c3d4e5b17324 https://doi.org/10.1002/ange.201305993 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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