Intrinsic and extrinsic flaws of the nomogram predicting bone-only metastasis in women with early breast cancer: An external validation study

Autor: Marie Chas, Marcos Ballester, Lobna Ouldamer, L Bédouet, Emile Daraï, L Boivin, Gilles Body, Sofiane Bendifallah
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Cancer Research
genetic structures
Receptor
ErbB-2
Triple Negative Breast Neoplasms
urologic and male genital diseases
Mastectomy
Segmental
Metastasis
0302 clinical medicine
Mastectomy
Early breast cancer
Aged
80 and over
Brain Neoplasms
Carcinoma
Ductal
Breast
Middle Aged
Prognosis
Neoadjuvant Therapy
Receptors
Estrogen
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Cohort
Female
Breast carcinoma
Receptors
Progesterone
Adult
medicine.medical_specialty
Antineoplastic Agents
Hormonal
Bone Neoplasms
Breast Neoplasms
Decision Support Techniques
03 medical and health sciences
Young Adult
Breast cancer
Internal medicine
medicine
Humans
Generalizability theory
Aged
Retrospective Studies
business.industry
External validation
Nomogram
medicine.disease
Surgery
Carcinoma
Lobular
Nomograms
030104 developmental biology
business
Zdroj: European journal of cancer (Oxford, England : 1990). 69
ISSN: 1879-0852
Popis: Background The recently developed MDACC nomogram purports to predict the risk of bone-only metastasis in women with early breast carcinoma based on five clinical and pathological characteristics. We set out to externally validate and assess its robustness using a tertiary breast cancer centre database. Methods All consecutive women treated for early breast cancer in our centre between January 1989 and December 2013 and who had all the nomogram variables documented were eligible for analysis. Results We identified 1255 eligible women for external validation analysis. The median follow-up was 54 months (range: 1–312) and time to initial metastasis 20 months (range: 1–80). The correspondence between the actual bone-only metastasis and the nomogram predictions implied poor calibration of the nomogram in the validation cohort, be it in the whole cohort or when stratified by breast cancer subtype. Conclusion This external validation study of the MDACC nomogram showed limitations in its generalizability to a new and independent European patient population.
Databáze: OpenAIRE
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