Association between NAFLD and risk of prevalent chronic kidney disease: why there is a difference between east and west?

Autor: Haoyang Zhang, Xiaozhong Wang, Ming-Hua Zheng, Chuan-ming Hao, Yueyong Zhu, Su Lin, Jiaofeng Huang, Mingfang Wang, Zimu Wu, Min Zhang, Shiying Liu, Su-mei Wu, Wen-Yue Liu, Dong-Chu Zhang
Rok vydání: 2020
Předmět:
Adult
Male
China
Chronic renal disease
medicine.medical_specialty
Population
Datasets as Topic
Renal function
Disease
urologic and male genital diseases
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Prevalence
medicine
Humans
Renal Insufficiency
Chronic
lcsh:RC799-869
Risk factor
education
education.field_of_study
Proteinuria
business.industry
Fatty liver
Gastroenterology
General Medicine
Middle Aged
Nutrition Surveys
medicine.disease
United States
female genital diseases and pregnancy complications
Cross-Sectional Studies
030220 oncology & carcinogenesis
Albuminuria
Female
lcsh:Diseases of the digestive system. Gastroenterology
030211 gastroenterology & hepatology
medicine.symptom
business
Research Article
Non-alcoholic fatty liver disease
Kidney disease
Zdroj: BMC Gastroenterology, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Gastroenterology
ISSN: 1471-230X
Popis: Backgrounds There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China. Methods Two health examination datasets from China and the US were used. CKD was defined as an estimated glomerular filtration rate (eGFR) 2 or and/or abnormal albuminuria and/or overt proteinuria. Binary logistic regression was used to examine the association between NAFLD and CKD. Results A total of 60,965 participants were analyzed, including 11,844 from the US and 51,229 from China. The prevalence of NAFLD was 27.12% in the Chinese population and 36.08% in the US population (p Conclusion NAFLD increased the risk of early stages of CKD in both Chinese and the US population. The conflicting results reported by previous studies might result from the different proportion of late stages of CKD.
Databáze: OpenAIRE
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