SUN-121 Vitamin D Repletion and Sitagliptin Administration is Associated with an Increase in Serum C-Peptide and a Decrease in GAD-65 Antibody and Hemoglobin A1c in a Patient with Latent Autoimmune Diabetes of Adults
| Autor: | Nicholette Fox, Heidi Peynado De Pena, Alan Sacerdote, Gul Bahtiyar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Latent autoimmune diabetes of adults
medicine.medical_specialty biology endocrine system diseases C-peptide business.industry Endocrinology Diabetes and Metabolism Glutamate decarboxylase nutritional and metabolic diseases medicine.disease Diabetes Mellitus and Glucose Metabolism chemistry.chemical_compound Endocrinology chemistry Sitagliptin Internal medicine medicine biology.protein Vitamin D and neurology Unusual Presentations and Complications of Diabetes I Hemoglobin Antibody business medicine.drug |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| Popis: | Background: Latent Autoimmune Diabetes of Adults (LADA) is characterized by adult onset and circulating autoantibodies e.g. glutamic acid decarboxylase (GAD-65), islet cell antibodies (ICA), and tyrosine phosphate related islet antigen 2 (IA-2). LADA may be misdiagnosed as it has features of both Type 1 (T1DM) and Type 2 (T2DM) diabetes. Dipeptidyl Peptidase-4 (DPP-4) (CD26) is a transmembrane glycoprotein immunomodulator causing a Th1/Th17 dominant milieu while suppressing anti-autoimmune Th2/Treg expression. Th1 and Th17 secrete pro-inflammatory cytokines that mediate β cell autoreactivity. DPP-4 inhibitors (DPP4I), e.g. sitagliptin (S), preserve β cell function, resulting in higher C-peptide levels, suggesting their potential use in LADA. Sustained remission of T1DM was reported in 2 patients with S and Vitamin D (D), leading us to explore their use in LADA. Clinical Case: Our patient is a 45-year-old Hispanic female with a 2 year history of diabetes. She was presumed to have T2DM and was first treated with diet, exercise and metformin, starting in 07/2016. At diagnosis, BMI was 16.16 kg/m² and HbA1c was 10.5% ( |
| Databáze: | OpenAIRE |
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