Is there an association between commonly employed biomarkers of liver fibrosis and liver stiffness in the general population?
| Autor: | Foschi F. G., Domenicali M., Giacomoni P., Dall'Aglio A. C., Conti F., Borghi A., Bevilacqua V., Napoli L., Mirici F., Cucchetti A., Ercolani G., Gardini A. C., Bellentani S., Gastaldelli A., Giuffre M., Tiribelli C., Bedogni G., BEDOGNI, GIORGIO |
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| Přispěvatelé: | Foschi F.G., Domenicali M., Giacomoni P., Dall'Aglio A.C., Conti F., Borghi A., Bevilacqua V., Napoli L., Mirici F., Cucchetti A., Ercolani G., Gardini A.C., Bellentani S., Gastaldelli A., Giuffre M., Tiribelli C., Bedogni G. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male Percentile Cross-sectional study Epidemiology Specialties of internal medicine Chronic liver disease Gastroenterology 0302 clinical medicine Non-alcoholic Fatty Liver Disease Medicine Metabolic Syndrome education.field_of_study Elasticity imaging technique Alanine Transaminase gamma-Glutamyltransferase General Medicine Middle Aged RC581-951 030220 oncology & carcinogenesis Elasticity Imaging Techniques Biomarker (medicine) Female 030211 gastroenterology & hepatology Fatty Liver Alcoholic Adult medicine.medical_specialty Population Liver fibrosis 03 medical and health sciences Internal medicine BAAT Humans Clinical significance Aspartate Aminotransferases Obesity education Hepatology Platelet Count business.industry Cholesterol HDL Cholesterol LDL Biomarker Overweight medicine.disease business Transient elastography Biomarkers |
| Zdroj: | Annals of Hepatology, Vol 19, Iss 4, Pp 380-387 (2020) |
| ISSN: | 1665-2681 |
| Popis: | Introduction and objectives Surrogate biomarkers of liver fibrosis developed in tertiary care are increasingly used in general populations. We evaluated the association between liver stiffness (LS) and five continuous (AST/ALT, APRI, Forns Index, FIB-4, GGT) and two discrete biomarkers (BARD, BAAT) in a general population. Patients and methods 636 (29%) of the 2159 citizens of the Bagnacavallo Study had LS measured by transient elastography. Using linear regression with univariate multiple imputation, we evaluated the association of LS with the above biomarkers in the total sample of 2159 citizens. Results The mean change of LS between the 5th and 95th internal percentile of any continuous biomarker was ≤1 kPa. The mean change of LS between scores 0 and 3 of BARD and scores 0 and ≥3 of BAAT was >1 kPa but of doubtful clinical relevance. Conclusion We found a modest association between LS and seven biomarkers of liver fibrosis in a general population. |
| Databáze: | OpenAIRE |
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