Bacterial metabolism-inspired molecules to modulate antibiotic efficacy
| Autor: | Zhiqiang Wang, Xia Xiao, Ruichao Li, Yuan Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Microbiology (medical) biology Bacteria medicine.drug_class 030106 microbiology Antibiotics Microbial metabolism Drug resistance biology.organism_classification Antimicrobial Microbiology Pathogenic organism Anti-Bacterial Agents 03 medical and health sciences 030104 developmental biology Infectious Diseases Drug development Drug Development Drug Resistance Bacterial medicine Escherichia coli Pharmacology (medical) |
| Zdroj: | The Journal of antimicrobial chemotherapy. 74(12) |
| ISSN: | 1460-2091 |
| Popis: | The decreasing antibiotic susceptibility of bacterial pathogens calls for novel antimicrobial therapies. Traditional screening pathways based on drug–target interaction have gradually reached the stage of diminishing returns. Thus, novel strategies are urgently needed in the fight against antibiotic-refractory bacteria, particularly for tolerant bacteria. Recently, evidence has accumulated demonstrating that microbial changes caused by bacterial metabolic processes significantly modulate antibiotic killing. A better understanding of these bacterial metabolic processes is indicating a need to screen novel metabolic modulators as potential antibiotic adjuvants. In this review, we describe the state of our current knowledge about how these bacterial metabolism-inspired molecules affect antibiotic efficacy, including potentiation and inhibition activity. In addition, the challenges faced and prospects for bringing them into clinic are also discussed. These examples may provide candidates or targets for the development of novel antibiotic adjuvants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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