| Autor: |
Lekshmi R. Nath, Gopika Chandrababu, Sunil Kumar Sah, Ayana R. Kumar, Sabitha M |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Recent Patents on Anti-Cancer Drug Discovery. 18:268-291 |
| ISSN: |
1574-8928 |
| Popis: |
Abstract: Green nanotechnology can offer notable advantages over the conventional drug delivery methods in terms of improved drug stability, drug-carrying capacity, site-specificity, and feasibility to apply different routes of administration with less systemic toxicities. Metal nanoparticles bio fab-ricated with phytoconstituents and microbial extracts have gained significant interest for the treatment of various solid tumors including hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is an aggressive cancer with a very poor prognosis. The current treatments of HCC fails to provide tumor specificity, causing many systemic toxicities and poor overall survival benefits especially for patients in advanced and terminal stages. A novel therapeutic approach with maximal therapeutic effect and minimum adverse effects are urgently required for HCC patients. Green synthesized metal nanopar-ticles offer significant anticancer effects along with minimal systemic toxicities because of their site-specific delivery into the tumor microenvironment (TME). Green synthesized metal nanoparticles can therefore be a highly beneficial strategy for the treatment of HCC if properly validated with pre-clinical and clinical studies. This review focuses on the preclinical evidence of the most widely stud-ied green metal nanoparticles such as green synthesized silver nanoparticles, gold nanoparticles and selenium nanoparticles. We have also summarised the clinical studies and the patents approved for nanoparticles against HCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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