Endoscopic Trimodal Imaging Detects Colonic Neoplasia as Well as Standard Video Endoscopy
| Autor: | Willem A. Marsman, Frank J.C. van den Broek, Paul Fockens, Teaco Kuiper, Jeroen M. Jansen, Rosalie Ch. Mallant–Hent, Anton H. Naber, Jacques J. Bergman, Evelien Dekker, Jan M. H. van den Brande, Pieter Scholten, Ellert J. van Soest, Arnoud H. Van Oijen |
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| Přispěvatelé: | Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Gastroenterology and Hepatology |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Video endoscopy Optical Phenomena Colorectal cancer Colon Biopsy Video Recording Colonoscopy Colonic Polyps Sensitivity and Specificity Fluorescence Article Diagnosis Differential Predictive Value of Tests Medicine Humans Aged Netherlands Narrow-band imaging Chi-Square Distribution Hepatology medicine.diagnostic_test Colonoscopes business.industry Carcinoma Gastroenterology Middle Aged medicine.disease Endoscopy High resolution endoscopy Logistic Models Female Radiology Detection rate business Colorectal Neoplasms |
| Zdroj: | Gastroenterology, 140(7), 1887-1894. W.B. Saunders Ltd |
| ISSN: | 0016-5085 |
| DOI: | 10.1053/j.gastro.2011.03.008 |
| Popis: | Background & Aims Endoscopic trimodal imaging (ETMI) is a novel endoscopic technique that combines high-resolution endoscopy (HRE), autofluorescence imaging (AFI), and narrow-band imaging (NBI) that has only been studied in academic settings. We performed a randomized, controlled trial in a nonacademic setting to compare ETMI with standard video endoscopy (SVE) in the detection and differentiation of colorectal lesions. Methods The study included 234 patients scheduled to receive colonoscopy who were randomly assigned to undergo a colonoscopy in tandem with either ETMI or SVE. In the ETMI group (n = 118), first examination was performed using HRE, followed by AFI. In the other group, both examinations were performed using SVE (n = 116). In the ETMI group, detected lesions were differentiated using AFI and NBI. Results In the ETMI group, 87 adenomas were detected in the first examination (with HRE), and then 34 adenomas were detected during second inspection (with AFI). In the SVE group, 79 adenomas were detected during the first inspection, and then 33 adenomas were detected during the second inspection. Adenoma detection rates did not differ significantly between the 2 groups (ETMI: 1.03 vs SVE: 0.97, P = .360). The adenoma miss-rate was 29% for HRE and 28% for SVE. The sensitivity, specificity, and accuracy of NBI in differentiating adenomas from nonadenomatous lesions were 87%, 63%, and 75%, respectively; corresponding values for AFI were 90%, 37%, and 62%, respectively. Conclusions In a nonacademic setting, ETMI did not improve the detection rate for adenomas compared with SVE. NBI and AFI each differentiated colonic lesions with high levels of sensitivity but low levels of specificity. |
| Databáze: | OpenAIRE |
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