Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy

Autor: Ying-Hsia Shih, Ming-Cheng Chang, Cheng-Liang Peng, Chun-Tang Chen, Ping-Fang Chiang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Near-Infrared Fluorescence Imaging
Nuclear imaging
Lutetium
Theranostic Nanomedicine
Mice
chemistry.chemical_compound
Medicine
Cyanine
Biology (General)
Spectroscopy
nuclear imaging
Quinolinium Compounds
Optical Imaging
General Medicine
Computer Science Applications
Chemistry
Female
multi-modality
Single Photon Emission Computed Tomography Computed Tomography
photothermal therapy
QH301-705.5
Mice
Nude
cyanine dye
Article
Catalysis
Inorganic Chemistry
near-infrared fluorescence imaging
In vivo
Spect imaging
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
neoplasms
Fluorescent Dyes
Radioisotopes
business.industry
Organic Chemistry
Cancer
Neoplasms
Experimental
Photothermal therapy
HCT116 Cells
medicine.disease
targeted radionuclide therapy
chemistry
A549 Cells
Cancer cell
Cancer research
business
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12214, p 12214 (2021)
ISSN: 1422-0067
DOI: 10.3390/ijms222212214
Popis: Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of cancer. In this study, synthesis, characterization, in vitro, and in vivo biological evaluation of the cyanine-based probe (DOTA-NIR790) were demonstrated. The use of cyanine dyes for the selective accumulation of cancer cells were used to achieve the characteristics of tumor markers. Therefore, all kinds of organ tumors can be targeted for diagnosis and treatment. The DOTA-NIR790 labeled with lutetium-111 could detect original or metastatic tumors by using SPECT imaging and quantify tumor accumulation. The β-emission of 177Lu-DOTA-NIR790 can be used for targeted radionuclide therapy of tumors. The DOTA-NIR790 enabled imaging by NIR fluorescence and by nuclear imaging (SPECT) to monitor in real-time the tumor accumulation and the situation of cancer therapy, and to guide the surgery or the photothermal therapy of the tumor. The radionuclide-labeled heptamethine cyanine based probe (DOTA-NIR790) offers multifunctional modalities for imaging and therapies of cancer.
Databáze: OpenAIRE
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