CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Autor:	Kai Gao, Qianle Yu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Cancer Research Carcinoma Hepatocellular proliferation Receptors Cell Surface Biochemistry 03 medical and health sciences 0302 clinical medicine Cell Movement Cell Line Tumor Genetics Carcinoma Medicine Humans Lectins C-Type Molecular Biology Cell Proliferation Janus kinase 1 Oncogene business.industry Liver Neoplasms apoptosis Cancer Articles C-type lectin domain family 4 member M hepatocellular carcinoma Cell cycle medicine.disease Prognosis Survival Analysis digestive system diseases Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology Oncology Tumor progression 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research STAT protein Disease Progression Molecular Medicine business Cell Adhesion Molecules Signal Transduction
Zdroj:	Molecular Medicine Reports
ISSN:	1791-3004 1791-2997
Popis:	Hepatocellular carcinoma (HCC) remains the most common malignant cancer worldwide. Numerous studies have indicated that C‑type lectin domain family 4 member M (CLEC4M) is associated with tumor progression; however, the biological functions of CLEC4M in HCC have not been investigated. In the present study, CLEC4M overexpression was observed to be associated with a favorable patient overall, relapse‑free, progression‑free and disease‑specific survival by using the KMplot™ database. The present study then concentrated specifically on the functions of CLEC4M by performing cell counting kit‑8 proliferation, 5‑Ethynyl‑2'‑deoxyuridine and flow cytometric assays. CLEC4M overexpression inhibited proliferation and enhanced apoptosis in Huh7 and PLC/PRF/5 cells. Furthermore, the results demonstrated by using western blotting that CLEC4M overexpression inhibited the Janus kinase 1/signal transducer and activator of transcription 3 pathway, which is involved in various types of tumors including HCC. In conclusion, the present study reported that CLEC4M may be considered as a novel indicator of HCC and may provide a theoretical basis for improving the survival of patients with HCC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f4b126989a3703e1ff277e4b06d7b1 http://europepmc.org/articles/PMC7411413 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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