Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering
| Autor: | Clare Francesca Carasco, Zakareya Gamie, Eleftherios Tsiridis, Athanasios Mantalaris, Quen Oak Tang, Nectarios Korres |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Cartilage Articular medicine.medical_specialty Scaffold Tissue Engineering business.industry Cartilage Regeneration (biology) Clinical Biochemistry Mesenchymal stem cell Mesenchymal Stem Cells Osteoarthritis medicine.disease Chondrogenesis Surgery medicine.anatomical_structure Tissue engineering Drug Discovery medicine Cancer research Humans business Stem cell transplantation for articular cartilage repair |
| Zdroj: | Expert opinion on biological therapy. 12(10) |
| ISSN: | 1744-7682 |
| Popis: | With an ageing population, the prevalence of osteoarthritis (OA) has increased. Mesenchymal Stem Cells (MSCs) have been proposed to be an attractive alternative candidate in the tissue engineering of articular cartilage primarily due to its abundant source, reduced cartilage donor site morbidity, and strong capacity for proliferation and potential to differentiate toward a chondrogenic phenotype.A current overview of human, in vivo, and in vitro evidence on the use of MSCs in cartilage tissue engineering.We demonstrate robust evidence that MSCs have the potential to regenerate articular cartilage. We also identify the complexity of designing a suitable preclinical model and the challenges in considering its clinical application such as type of MSC, scaffold, culture construct and the method by which growth factors are delivered. Of great interest is further characterization of the factors that may prevent MSC-derived chondrocytes to undergo premature hypertrophy and to understand what enables the terminal developmental pathway for permanent hyaline cartilage regeneration. Despite this, there is an abundance of evidence suggesting that MSCs are a desirable cell source and will have significant impact in tissue engineering of cartilage in the future. |
| Databáze: | OpenAIRE |
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