Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures
| Autor: | Pierre-Olivier Polack, Emilie Hu, Antoine Depaulis, Isabelle Guillemain, Colin Deransart, Stéphane Charpier |
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| Přispěvatelé: | Dynamique et physiopathologie des réseaux neuronaux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collaboration, Deransart, Colin, Centre interdisciplinaire de recherche en biologie (CIRB), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Rok vydání: | 2007 |
| Předmět: |
Periodicity
MESH: Periodicity [SDV]Life Sciences [q-bio] MESH: Neurons Action Potentials Somatosensory system Epilepsy 0302 clinical medicine MESH: Animals MESH: Models Genetic MESH: Action Potentials MESH: Brain Mapping MESH: Epilepsy Absence Neurons Brain Mapping 0303 health sciences General Neuroscience Articles [SDV] Life Sciences [q-bio] medicine.anatomical_structure Cerebral cortex Psychology MESH: Face Cortical Synchronization MESH: Rats Thalamus Biotin MESH: Somatosensory Cortex 03 medical and health sciences MESH: Analysis of Variance MESH: Biotin Genetic model medicine Animals Ictal Rats Wistar Wakefulness 030304 developmental biology Analysis of Variance Models Genetic Spike-and-wave Somatosensory Cortex MESH: Rats Wistar medicine.disease Rats MESH: Wakefulness Epilepsy Absence Face Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, 2007, 27 (24), pp.6590-9. ⟨10.1523/JNEUROSCI.0753-07.2007⟩ Journal of Neuroscience, Society for Neuroscience, 2007, 27 (24), pp.6590-9. ⟨10.1523/JNEUROSCI.0753-07.2007⟩ |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.0753-07.2007 |
| Popis: | International audience; Typical absence has long been considered as the prototypic form of generalized nonconvulsive epileptic seizures. Recent investigations in patients and animal models suggest that absence seizures could originate from restricted regions of the cerebral cortex. However, the cellular and local network processes of seizure initiation remain unknown. Here, we show that absence seizures in Genetic Absence Epilepsy Rats from Strasbourg, a well established genetic model of this disease, arise from the facial somatosensory cortex. Using in vivo intracellular recordings, we found that epileptic discharges are initiated in layer 5/6 neurons of this cortical region. These neurons, which show a distinctive hyperactivity associated with a membrane depolarization, lead the firing of distant cortical cells during the epileptic discharge. Consistent with their ictogenic properties, neurons from this "focus" exhibit interictal and preictal oscillations that are converted into epileptic pattern. These results confirm and extend the "focal hypothesis" of absence epilepsy and provide a cellular scenario for the initiation and generalization of absence seizures. |
| Databáze: | OpenAIRE |
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