Structural Long-Term Changes at Mushroom Body Input Synapses
| Autor: | Florian Leiss, Peter Kloppenburg, Gaia Tavosanis, Till F. M. Andlauer, Stephan J. Sigrist, Frauke Christiansen, Friedrich Forstner, Moritz Paehler, Stephan Knapek, Malte C. Kremer |
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| Rok vydání: | 2010 |
| Předmět: |
Potassium Channels
Recombinant Fusion Proteins Action Potentials Sensory system Cellular level Neurotransmission Biology Synaptic Transmission General Biochemistry Genetics and Molecular Biology Calyx Postsynaptic potential Animals Drosophila Proteins Active zone Mushroom Bodies Neurons Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) fungi Anatomy Smell Brain region nervous system Synapses Mushroom bodies Drosophila General Agricultural and Biological Sciences Neuroscience |
| Zdroj: | Current Biology. 20(21):1938-1944 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2010.09.060 |
| Popis: | SummaryHow does the sensory environment shape circuit organization in higher brain centers? Here we have addressed the dependence on activity of a defined circuit within the mushroom body of adult Drosophila. This is a brain region receiving olfactory information and involved in long-term associative memory formation [1]. The main mushroom body input region, named the calyx, undergoes volumetric changes correlated with alterations of experience [2–5]. However, the underlying modifications at the cellular level remained unclear. Within the calyx, the clawed dendritic endings of mushroom body Kenyon cells form microglomeruli, distinct synaptic complexes with the presynaptic boutons of olfactory projection neurons [6, 7]. We developed tools for high-resolution imaging of pre- and postsynaptic compartments of defined calycal microglomeruli. Here we show that preventing firing of action potentials or synaptic transmission in a small, identified fraction of projection neurons causes alterations in the size, number, and active zone density of the microglomeruli formed by these neurons. These data provide clear evidence for activity-dependent organization of a circuit within the adult brain of the fly. |
| Databáze: | OpenAIRE |
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