Clozapine-related Sudden Pericarditis in a Patient Taking Long Acting Aripiprazole and Valproate: A Case Report
| Autor: | Domenico De Berardis, Francesco Nappi, Michele Fornaro, Luigi Olivieri, Nicola Serroni, F. Vellante, Massimo Di Giannantonio, Cosimo Napoletano, Laura Orsolini, Gabriella Rapini |
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| Přispěvatelé: | De Berardis, Domenico, Fornaro, Michele, Orsolini, Laura, Olivieri, Luigi, Nappi, Francesco, Rapini, Gabriella, Vellante, Federica, Napoletano, Cosimo, Serroni, Nicola, Di Giannantonio, Massimo |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Myocarditis Schizoaffective disorder Case Report Therapeutic drug monitoring 03 medical and health sciences Behavioral Neuroscience Pericarditis 0302 clinical medicine medicine Valproic acid Pericarditi Pharmacology (medical) Adverse effect Clozapine Valproate business.industry Panic medicine.disease Drug monitoring 030227 psychiatry Discontinuation Psychiatry and Mental health Long acting aripiprazole Polypharmacy Aripiprazole medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 2093-4327 1738-1088 |
| Popis: | Clozapine may be associated with cardiovascular adverse effects including QTc prolongation and, more rarely, with myocarditis and pericarditis. Although rare, these latter cardiovascular adverse effects may be life-threatening and must be immediately recognized and treated. Several cases of clozapine related-pericarditis have been described and often it has a subtle and insidious onset with symptoms that may be often misdiagnosed with psychiatric manifestations (e.g. anxiety, panic or somatization) leading to a delayed correct diagnosis with potential fatal consequences. In the present report we describe the case of a 27-year-old girl with schizoaffective disorder taking long acting aripiprazole and valproate who developed a sudden onset clozapine-related pericarditis during titration phase that resolved with immediate clozapine discontinuation and indomethacin administration. We underline the importance of an early diagnosis of clozapine- related pericarditis and the need to have monitoring protocols to prevent this potentially fatal adverse effect especially when polypharmacy is administered to patients taking clozapine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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