Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study
| Autor: | Caroline S. Fox, Udo Hoffmann, Patrice Sutherland, Kate E. Therkelsen, Alison Pedley, Tobin M. Abraham, Joseph M. Massaro |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
obesity Time Factors Epidemiology Physiology population Comorbidity 030204 cardiovascular system & hematology 0302 clinical medicine Framingham Heart Study Risk Factors Odds Ratio Longitudinal Studies Original Research 2. Zero hunger education.field_of_study Incidence Middle Aged Prognosis 3. Good health Massachusetts Cardiovascular Diseases Female Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty Population 030209 endocrinology & metabolism Risk Assessment 03 medical and health sciences Predictive Value of Tests Diabetes mellitus Internal medicine medicine Humans Risk factor education hormones business.industry Odds ratio medicine.disease Obesity Prolactin Endocrinology Logistic Models Multivariate Analysis Linear Models business Body mass index Biomarkers |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background Prolactin is an anterior pituitary hormone that may modulate the adverse effects of obesity. Prolactin has been associated with cardiovascular disease mortality, but less is known about whether prolactin predicts incidence of cardiovascular disease risk factors. Methods and Results Our sample (n=3232, mean age 40.4 years, 52.1% women) was drawn from Framingham Heart Study participants who attended 2 examinations an average of 6.1 years apart. After excluding those with elevated prolactin (>30 mg/dL for women, >20 mg/dL for men), multivariable‐adjusted regressions modeled the associations between baseline prolactin and changes in cardiovascular disease risk factors. Models were adjusted for age, sex, baseline value of the risk factor, smoking status, hormone replacement therapy, and menopausal status and additionally for body mass index. Mean prolactin levels were 11.9 mg/dL ( SD 5.2) in women and 8.0 mg/dL ( SD 2.9) in men. No associations were observed for change in weight, body composition, total cholesterol, triglycerides, or fasting glucose. In women, for example, for each 5‐mg/dL increment in prolactin, odds of incident hypercholesterolemia were 1.06, which was not significant (95% CI 0.91–1.23, P =0.46). Some exceptions were of note. In women, for each 5‐mg/dL increment in prolactin, we observed increased odds of low high‐density lipoprotein cholesterol at follow‐up (odds ratio 1.50, 95% CI 1.18–1.91, P =0.001) that persisted after adjustment for body mass index ( P =0.001). In men, a 5‐mg/dL increment in prolactin was associated with increased odds of incident hypertension (odds ratio 1.61, 95% CI 1.18–2.20 P =0.002) and incident diabetes (odds ratio 1.70, 95% CI 1.04–2.78, P =0.03). Conclusions Prolactin is not associated with a comprehensive panel of incident cardiovascular disease risk factors. Measurement of circulating prolactin levels in the community likely does not provide substantial insight into cardiometabolic risk. |
| Databáze: | OpenAIRE |
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