Quetiapine and Drug Interactions
| Autor: | Ingrid Castberg, Eirik Skogvoll, Olav Spigset |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Dibenzothiazepines medicine.medical_specialty Adolescent medicine.drug_class Atypical antipsychotic Pharmacology Lamotrigine Gastroenterology Hypnotic Levomepromazine Quetiapine Fumarate Internal medicine Methotrimeprazine medicine Humans Drug Interactions Clozapine Aged Aged 80 and over Dose-Response Relationship Drug medicine.diagnostic_test Oxazepam Triazines business.industry Age Factors Carbamazepine Middle Aged Psychiatry and Mental health Psychotic Disorders Fluvoxamine Therapeutic drug monitoring Quetiapine Female Drug Monitoring business Antipsychotic Agents medicine.drug |
| Zdroj: | The Journal of Clinical Psychiatry. 68:1540-1545 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.v68n1011 |
| Popis: | Objective: The objective of the present study was to investigate the effect of age, gender, and various comedications on the pharmacokinetics of quetiapine in a naturalistic setting. Method: In total, 2111 serum samples analyzed for quetiapine during the period from June 2001 to December 2004 were included in the study. The samples had been collected for routine therapeutic drug monitoring purposes from 1179 patients treated with quetiapine. A log-linear mixed model was used to identify factors influencing the dose-corrected quetiapine serum concentration, expressed as the quetiapine concentration-to-dose (C/D) ratio. Variables included in the analysis were age, gender, and concomitant treatment with a total of 41 drugs most often used in combination with quetiapine. Results: Age ≥ 70 years (p =.001) and comedication with alimemazine (p =.002), fluvoxamine (p =.001), citalopram/escitalopram (p =.041), or clozapine (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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