Histopathological changes in anatomical distribution of inflammatory bowel disease in children: a retrospective cohort study
| Autor: | Sheena Sikora, Donald W. Spady, Jessica Tsang, Wael El-Matary |
|---|---|
| Přispěvatelé: | University of Manitoba |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Adolescent IBD Inflammatory bowel disease Gastroenterology Cohort Studies Internal medicine medicine Humans Distribution (pharmacology) Pediatrics Perinatology and Child Health Child Children Retrospective Studies business.industry lcsh:RJ1-570 Retrospective cohort study lcsh:Pediatrics Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Child Preschool Pediatrics Perinatology and Child Health Disease Progression Female Crohn’s business Research Article |
| Zdroj: | BMC Pediatrics, Vol 12, Iss 1, p 162 (2012) BMC Pediatrics |
| ISSN: | 1471-2431 |
| Popis: | Background Anatomical progression of pediatric inflammatory bowel disease is under-reported. The aim of this work was to examine possible changes in the anatomical distribution of IBD in pediatric patients at diagnosis and at follow up. Methods In a retrospective cohort study, the medical records of children with inflammatory bowel disease were examined. Patients who had at least 2 endoscopic/colonoscopic examinations were included. Primary outcome was histopathological progression based on histopathological examination of biopsies taken during endoscopic and colonoscopic bowel examination. Factors predictive of disease progression were also examined. Results A total of 98 patients fulfilled inclusion criteria (49 female, 54 with ulcerative colitis, range 2 – 17 years, mean age at diagnosis was 10.6 years, SD ± 3.67), the mean duration of follow up was 32.9 months (range 0.1 – 60 months, SD ± 8.54). In the ulcerative colitis group, 41% had disease progression and none of the examined variables (age, gender, laboratory markers, growth and disease activity at diagnosis) appeared to effect disease progression. In the Crohn’s disease group, 75% had disease progression. Girls (OR = 0.13, 95% CI 0.02 – 0.79) and patients with high erythrocytic sedimentation rate (OR=0.942, 95% CI 0.894 – 0.99) were predictive for disease progression. Conclusions Despite maximum therapy, the majority of children with Crohn’s disease appeared to have histopathological disease progression. Female sex and high erythrocytic sedimentation rate seemed to be predictive for disease progression. None of the factors analyzed seemed predictive of disease progression in ulcerative colitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink