Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
| Autor: | Pilar Amiano, Gemma Castaño-Vinyals, Lidia García-Martínez, Victor Moreno, Manuel Rivas-del-Fresno, Nuria Aragonés, Tania Fernández-Villa, Trinidad Dierssen-Sotos, Javier Llorca, Jéssica Alonso-Molero, José Juan Jiménez-Moleón, Marina Pollán, Camilo Palazuelos, Beatriz Pérez-Gómez, Ana Molina-Barceló, Eva Ardanaz, Paz Rodríguez-Cundín, Carmen Urtiaga, Manolis Kogevinas, Pablo Fernández-Navarro, Inés Gómez-Acebo |
|---|---|
| Přispěvatelé: | Universidad de Cantabria, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Fundación Marqués de Valdecilla, International Cancer Genome Consortium, Ministerio de Economía y Competitividad (España), Red Temática de Investigación Cooperativa en Cáncer (España), Junta de Castilla y León (España), Regional Government of Andalusia (España), Generalitat Valenciana (España), Fundación La Caixa, Basque Government (España), Gobierno de la Región de Murcia (España), Unión Europea. Comisión Europea, Asociación Española Contra el Cáncer, Government of Catalonia (España), Fundación Caja de Ahorros de Asturias, University of Oviedo (España), Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Pròstata -- Càncer -- Aspectes genètics Mama -- Càncer -- Aspectes genètics Male Organic chemistry lcsh:Medicine Prostate cancer 0302 clinical medicine Breast cancer Prostate Breast Tumors Medicine and Health Sciences Vitamin D lcsh:Science Aged 80 and over Multidisciplinary Eye Color Pigmentation Prostate Cancer Confounding Prostate Diseases Photodermatology and Skin Aging Mendelian Randomization Analysis Vitamins Middle Aged Phototype Physical sciences Fenotip Phenotypes Chemistry medicine.anatomical_structure Phenotype 030220 oncology & carcinogenesis Female Anatomy Research Article Adult medicine.medical_specialty Medicina Urology Breast Neoplasms Dermatology Polymorphism Single Nucleotide Càncer de mama 03 medical and health sciences Chemical compounds Young Adult Exocrine Glands Ocular System Internal medicine Breast Cancer Organic compounds medicine Genetics Humans Genetic Predisposition to Disease Phototype and breast Espanya Aged Càncer de pròstata business.industry lcsh:R Case-control study Cancer Cancers and Neoplasms Biology and Life Sciences Prostatic Neoplasms medicine.disease Hormones Genitourinary Tract Tumors 030104 developmental biology Spain Case-Control Studies Eyes Prostate Gland Genetic pigmentation lcsh:Q sense organs business Head |
| Zdroj: | PLoS ONE, Vol 13, Iss 8, p e0201750 (2018) Biblos-e Archivo. Repositorio Institucional de la UAM instname PLoS One. 2018 Aug 14;13(8):e0201750 PLoS ONE Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Recercat. Dipósit de la Recerca de Catalunya UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) Repisalud Instituto de Salud Carlos III (ISCIII) PLoS One r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1932-6203 |
| Popis: | Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. Methods We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype—cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. Results The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. Conclusions Phototype is not associated with breast or prostate cancer. This work was partially funded by the ªAccion Transversal del Cáncer", approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/ 01403, PI11/01889-FEDER, PI11/00226, PI11/ 01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/ 0036/0036)); The Junta de Castilla y León [LE22A10-2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOOD-CT-2006-036224- HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|