The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease
| Autor: | Mehmet Ekinci, Turgay Isik, Mahmut Acikel, Ibrahim Halil Tanboga, Mehmet Ali Kaygın, Serdar Sevimli, Mustafa Kurt, Enbiya Aksakal, Ahmet Kaya |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Turkey Population Coronary Artery Disease Kaplan-Meier Estimate Coronary Angiography Risk Assessment Severity of Illness Index digestive system Coronary artery disease Risk Factors Internal medicine Myocardial Revascularization Odds Ratio Humans Medicine education Survival analysis Aged Proportional Hazards Models education.field_of_study Chi-Square Distribution Ejection fraction business.industry Proportional hazards model gamma-Glutamyltransferase Coronary Lesion Complexity Odds ratio Middle Aged Prognosis medicine.disease digestive system diseases Logistic Models Multivariate Analysis Cardiology Population study Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Atherosclerosis. 221:596-601 |
| ISSN: | 0021-9150 |
| Popis: | Background Relation of serum gamma-glutamyl transferase (GGT) levels with extent, severity, and complexity of coronary artery disease has not been adequately studied. Therefore, we evaluated the relationship between GGT levels and coronary complexity, severity and extent assessed by SYNTAX score and long-term adverse events. Methods We enrolled 442 consecutive patients with stable angina pectoris who underwent coronary angiography. Baseline serum GGT levels were measured and SYNTAX score was calculated from the study population. Median follow-up duration was 363 days. Endpoints were all cause mortality and any revascularization. Results GGT levels demonstrated an increase from low SYNTAX tertile to high tertile. In multivariate analysis serum GGT, diabetes mellitus, HDL-cholesterol, eGFR and ejection fraction were found to be independent predictors of high SYNTAX score. The survival analysis showed that long-term revascularization rates were comparable between the GGT groups (for 36 U/l cut point) of the overall population (7.7% vs 8.6% logrank, p = 0.577), whereas long-term all cause mortality rate was higher in the GGT ≥ 36 U/l group (3.6% vs 11.6% logrank, p = 0.001). In Cox proportional hazards regression model, GGT ≥ 36 U/l group was found to be an independent predictor of long-term all cause mortality in the unadjusted (HR 2.54, 95% CI 1.17–5.48, p = 0.018) and age- and gender-adjusted (HR 2.58, 95% CI 1.19–5.58, p = 0.016) models. Conclusion Serum GGT level was independently associated with coronary complexity and long-term mortality in patients with stable coronary artery disease. |
| Databáze: | OpenAIRE |
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