Gestational age-related inhibition of placental hCG, alpha hCG and steroid hormone release in vitro by a GnRH antagonist
| Autor: | Theresa M. Siler-Khodr, J.J. Nestor, G.S. Khodr, J. Rhode, B.H. Vickery |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
endocrine system
medicine.medical_specialty Time Factors Estrone medicine.medical_treatment Placenta Radioimmunoassay Endogeny Gestational Age Peptide hormone Biology Chorionic Gonadotropin Pituitary Hormones Anterior Pregnancy Internal medicine Culture Techniques medicine Humans reproductive and urinary physiology Progesterone Pituitary Hormone Release Inhibiting Hormones Estradiol Antagonist Obstetrics and Gynecology Placental Lactogen Peptide Fragments Steroid hormone Endocrinology medicine.anatomical_structure Reproductive Medicine Cell culture Glycoprotein Hormones alpha Subunit Gestation Female Placental Hormones hormones hormone substitutes and hormone antagonists Developmental Biology Hormone |
| Zdroj: | Placenta. 8(1) |
| ISSN: | 0143-4004 |
| Popis: | Human placental tissues have been shown to contain gonadotrophin-releasing hormone-(GnRH)-like activity. Thus, the effect of a potent GnRH antagonist (N-Ac-Pro1, d -p-Cl-Phe2, d -Nal(2)3,6-GnRH, obtained from Syntex Laboratories) on placental hormonal release was studied. Explant cultures of placentae of 6 to 15 weeks' gestation were studied. This GnRH antagonist did not inhibit the alpha human chorionic gonadotrophin (αhCG), human chorionic gonadotrophin (hCG), oestrone or oestradiol release from the six- and nine-week placental cultures, but greatly suppressed the release of these hormones in the placental cultures from 13- and 15-week gestations. Synthetic GnRH partially reversed the action of this antagonist on the hormonal releases in the 15-week placental cultures. These data demonstrate a gestational age-related action of this antagonist on placental hormonal release. Thus, a role for the endogenous GnRH-like activity of the placenta in the control of placental hormonogenesis is indicated. |
| Databáze: | OpenAIRE |
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