Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract
| Autor: | Hurkan Kerimoglu, M. Zeki Bayraktar, Cüneyt Erdurman, Volkan Hurmeric, Ali Hakan Durukan, Tarkan Mumcuoglu, Cem Evereklioglu |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty food.ingredient genetic structures medicine.medical_treatment Administration Oral medicine.disease_cause Cataract Rats Sprague-Dawley chemistry.chemical_compound food Sodium Selenite Internal medicine Malondialdehyde Lens Crystalline medicine Ingestion Animals Proanthocyanidins Saline IH636 grape seed proanthocyanidin extract Grape Seed Extract business.industry Plant Extracts fungi food and beverages Glutathione Free Radical Scavengers Sensory Systems eye diseases Surgery Diet Rats Ophthalmology Disease Models Animal Oxidative Stress Endocrinology chemistry Proanthocyanidin Grape seed extract Female business Oxidative stress |
| Zdroj: | Journal of cataract and refractive surgery. 32(6) |
| ISSN: | 0886-3350 |
| Popis: | To investigate whether dietary supplementation with IH636 grape seed proanthocyanidin extract (GSPE) prevents selenite-induced cataract.Department of Ophthalmology, Gulhane Military Medical Academy, Ankara, Turkey.Thirty Spraque-Dawley rat litters were put randomly into 3 groups. In group 1 (n = 10), sodium selenite (30 nmol/g body weight) was injected subcutaneously on postpartum day 10. In group 2 (n = 10), sodium selenite (30 nmol/g body weight) was injected on postpartum day 10 and oral GSPE (100 mg/kg body weight) was given for 1 week after sodium selenite injection. Only subcutaneous saline was injected in group 3 (control, n = 10). The development of cataract was assessed for 3 weeks, and its density was graded and photographed with a slitlamp. Removed rat lenses were analyzed for glutathione (GSH) and malondialdehyde (MDA).All of the rats in group 1 had cataract between stage 6 and stage 3. In group 2, only 5 of 10 eyes had cataract between stage 3 and stage 2 and no cataract occurred in the remaining 5 rats. The difference between mean cataract stages in group 1 and group 2 was significant (P.05). The mean GSH level in group 1 was significantly lower than in group 2 and controls (P.05). The mean MDA level in group 1 was significantly higher than in group 2 and controls (P.05).IH636 grape seed proanthocyanidin extract effectively suppressed cataract formation in rats. Routine consumption of grape seed proanthocyanidin extract in the form of food or dietary supplement may offer a prophylactic measure against onset and progression of cataract. |
| Databáze: | OpenAIRE |
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