Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions
| Autor: | Jochen Zange, O. Kos, R. M. Gorczynski, Floris L. Wuyts, Jörn Rittweger, Dag Linnarsson, William H. Paloski, D. A. Hart, Gilles Clément, Petra Frings-Meuthen, Richard L. Hughson |
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| Přispěvatelé: | Burr, David |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Cell type Histology Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Receptors Cell Surface CD200R Bed rest Bone and Bones Collagen Type I Osteoclast Antigens CD Orexin Receptors Internal medicine medicine Humans Amino Acids Bone Resorption Receptor Weltraumphysiologie Messenger RNA biology Chemistry Tumor Necrosis Factor-alpha RANK Ligand Osteoblast Alkaline Phosphatase Transmembrane protein Peptide Fragments medicine.anatomical_structure Endocrinology Solubility CD200 Immunology Antigens Surface biology.protein Bed rest Study Calcium Human medicine Antibody Peptides Bed Rest Biomarkers Procollagen Artificial gravity |
| Zdroj: | Europe PubMed Central Bone |
| ISSN: | 1873-2763 8756-3282 |
| Popis: | CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200R5) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Previous studies have implicated a role for CD200:CD200R in the regulation of the expression of mRNA markers of osteoclastogenesis/osteoblastogenesis, following interaction of CD200 (on osteoblast precursors) with CD200R1 (on osteoclast precursors). Signaling of CD200R1 is hypothesized to attenuate osteoclastogenesis. We have investigated whether levels of soluble forms of CD200 and/or CD200R1 (sCD200, 5CD200R1) are altered in volunteers undergoing 6 head down tilt bed rest to mimic conditions of microgravity known to be associated with preferential osteoclastogenesis and whether countermeasures, reported to be beneficial in attenuation of bone loss under microgravity conditions, would lead to altered sCD200 and 5CD200R1 levels. Our data suggest that as predicted, sCD200 levels fall under bed rest conditions while sCD200R1 levels rise. In subjects undergoing 30-minute per day continuous centrifugation protocols, as a countermeasure to attenuate changes which may lead to bone loss, these alterations in 5CD200 and sCD200R1 levels seen under conditions of bed rest were abolished or attenuated. Our results suggest that measurement of 5CD200 and/or sCD200R1 May prove a useful and rapid means of monitoring subjects at risk of bone loss and/or accessing the efficacy of treatment regimes designed to counter bone loss. (C) 2013 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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